Relationship between vascular disease and age-associated changes in the human kidney

Kasiske, Bertram L.
May 1987
Kidney International;May1987, Vol. 31 Issue 5, p1153
Academic Journal
To investigate the relationship between atherosclerotic vascular disease and age-associated changes in the normal human kidney, autopsy findings and renal histology from 57 individuals with mild systemic atherosclerosis (group I), were compared to 57 sex- and age-matched individuals with moderate-to-severe atherosclerosis (group II). Age, sex, body build, the presence or absence of hypertension, semiquantitative aorta and coronary-artery atherosclerosis scores, organ weights, and the percent of globally sclerotic glomeruli were determined in each. Glomerular area, arcuate/interlobular arteries, and percent interstitial fibrosis were measured using standard morphometric techniques. Group 1 individuals had a 8.3 ± 7.0% incidence of sclerotic glomeruli, compared to 15.4 ± 16.3% in group II (mean ± SD, P < 0.01). Relative intrarenal arterial wall area was increased in group II (60 ± 12%) compared to group I (55 ± 11%, P < 0.05). The mean glomerular area of nonsclerotic glomeruli was greater in group II (23,700 ± 6,000 sq μ) than in group I (19,600 ± 3,700 sq μ, P < 0.01), suggesting that there were compensatory increases in glomerular size in group II. Interstitial fibrosis was similar in both groups. The relative impact of age, sex, body build, hypertension, systemic atherosclerosis, intrarenal vascular disease and interstitial fibrosis on glomerulosclerosis and glomerular size was investigated using multiple linear regression. Both age and intrarenal vascular disease exhibited highly significant, independent associations with glomerulosclerosis. Glomerular area was positively correlated with heart weight and coronary artery atherosclerosis. In contrast, there was no independent correlation between glomerular area and glomerulosclerosis. These results indicated that a significant portion of the glomerulosclerosis that occurs in aging humans is linked to atherosclerosis. Age-associated compensatory increases in glomerular size, on the other hand. are related to heart disease, and not to glomerulosclerosis per se.


Related Articles

  • Renal Athersosclerotic reVascularization Evaluation (RAVE Study): Study protocol of a randomized trial [NCT00127738]. Tobe, Sheldon W.; Atri, M.; Perkins, N.; Pugash, R.; Bell, Chaim M. // BMC Nephrology;2007, Vol. 8, p1 

    Background: It is uncertain whether patients with renal vascular disease will have renal or mortality benefit from re-establishing renal blood flow with renal revascularization procedures. The RAVE study will compare renal revascularization to medical management for people with atherosclerotic...

  • Comparison of intima-media thickness of common and internal carotid arteries of patients with ischemic stroke and intracerebral hemorrhage. Moghtaderi, Ali; Sanei-Sistani, Sharareh; Abdollahi, Ghassem; Dahmardeh, Hamid // Iranian Journal of Neurology;2014, Vol. 13 Issue 4, p226 

    Background: Role of atherosclerosis in the pathogenesis of ischemic and hemorrhagic infarctions is still matter of debate. Intima-media thickness (IMT) of the common carotid artery (CCA) and internal carotid artery (ICA) are markers of atherosclerosis. The aim of this study was to compare CCA...

  • The Role of Mercury and Cadmium Heavy Metals in Vascular Disease, Hypertension, Coronary Heart Disease, and Myocardial Infarction. Houston, Mark C. // Alternative Therapies in Health & Medicine;Mar/Apr2007, Vol. 13 Issue 2, pS128 

    The article examines the role of mercury and cadmium toxicity in vascular diseases, hypertension, atherosclerosis, coronary heart disease and myocardial infarction. It states that mercury induces mitochondrial dysfunction that results to increase in oxidative stress and reduction in antioxidant...

  • Comprehensive Vascular Imaging with Whole Body MRI in Patients with Longstanding Diabetes. Findeisen, Hannes M.; Weckbach, Sabine; Schoenberg, Stefan O.; Stark, Renee G.; Parhofer, Klaus G. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA588 

    Background: Vascular disease, including coronary heart disease (CAD), peripheral vascular disease and cerebrovascular disease, is the major cause of morbidity and death in diabetes. A recently introduced MRI technique was used to obtain an extensive assessment (excluding coronaries) of the...

  • Progression of cardiac dysfunction in patients with atherosclerotic renovascular disease. WRIGHT, JULIAN R.; SHURRAB, ALA'A E.; COOPER, ANNE; KALRA, PAUL R.; FOLEY, ROBERT N.; KALRA, PHILIP A. // QJM: An International Journal of Medicine;Oct2009, Vol. 102 Issue 10, p695 

    Background: Patients with atherosclerotic renovascular disease (ARVD) are at increased risk of heart disease because of the association with hypertension, coronary artery disease, cardiac failure and chronic kidney disease (CKD). A previous echocardiographic cross-sectional study showed that...

  • Atherosclerotic renovascular disease in United States patients aged 67 years or older: Risk factors, revascularization, and prognosis. Kalra, Philip A.; Guo, Haifeng; Kausz, Annamaria T.; Gilbertson, David T.; Liu, Jiannong; Chen, Shu-Cheng; Ishani, Areef; Collins, Allan J.; Foley, Robert N. // Kidney International;Jul2005, Vol. 68 Issue 1, p293 

    Atherosclerotic renovascular disease in United States patients aged 67 years or older: Risk factors, revascularization, and prognosis. Background. Although atherosclerotic renovascular disease is increasingly recognized in chronic kidney disease, few national level studies have examined its...

  • Therapeutic Targeting of P-Selectin in Atherosclerosis. Woollard, Kevin J.; Chin-Dusting, Jaye // Inflammation & Allergy - Drug Targets;Jan2007, Vol. 6 Issue 1, p69 

    P-selectin is an inflammatory adhesion molecule expressed on activated platelets and endothelial cells. The role of inflammatory cells and adhesion molecules in the development and progression of vascular diseases has been well studied in the past two decades and it is now recognised that many...

  • plaque. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p612 

    An encyclopedia entry for "plaque" is presented. It refers to an area of atherosclerosis, or the fatty deposits within arteries. Based on the entry, the symptoms of plaque will manifest until it becomes large enough to impede blood flow. Coronary artery disease occurs when plaques form in...

  • Secondary Prevention of Atherothrombotic Events After Ischemic Stroke. Adams Jr, Harold P. // Mayo Clinic Proceedings;Jan2009, Vol. 84 Issue 1, p43 

    Atherosclerotic vascular disease Is the leading cause of Ischemic stroke, resulting in occlusive or severely stenotic lesions of major intracranial or extracranial arteries and narrowing of small penetrating arteries of the brain. Atherosclerosis of the coronary arteries (ie, coronary artery...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics