Humoral factors in regulation of compensatory renal hypertrophy

Malt, Ronald A.
April 1983
Kidney International;Apr1983, Vol. 23 Issue 4, p611
Academic Journal
Compensatory renal hypertrophy in transplanted kidneys shows that the major regulators arc humoral. Crosscirculation experiments are confirmatory indicating further that the regulators are short-lived and must be consistently present during the early phases of hypertrophy. Controls are difficult to achieve in other systems; variables relate to nutrition, means of assay, pharmacokinetics, and abnormalities produced by the experimental model itself. A simple hypothesis to account for the events precipitating renal hypertrophy might integrate the onsets of renal hyperemia soon after contralateral nephrectomy with the activation of pre-existing stimulators specific for the kidney.


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