Course and resolution of the coagulopathy in nephrotic children

Alkjaersig, Norma; Fletcher, Anthony P.; Narayanan, Manoj; Robson, Alan M.
March 1987
Kidney International;Mar1987, Vol. 31 Issue 3, p772
Academic Journal
Blood coagulation function was serially studied in 84 children with nephrotic syndrome. Fifty-eight had minimal change disease, six had focal glomerulosclerosis and 20 had other forms of renal disease associated with the nephrotic syndrome. Qualitatively similar abnormalities in fibrinogen metabolism were present in all groups with clinically overt nephrotic syndrome: plasma fibrinogen concentration and high molecular weight fibrin(ogen) complexes (HMWFC) were grossly elevated (P < 0.001 in most groups). With disease remission fibrinogen and HMWFC concentrations decreased to the normal range, usually with concomitant transient increase in plasma fibrinolytic activity (P < 0.02). Alterations in concentrations of other proteins involved in coagulation and fibrinolysis differed depending on the underlying cause for the nephrotic syndrome. Antithrombin III concentration was normal except in the focal glomerulosclerosis group. The results demonstrate that a coagulopathy characterized by pathological degree of thrombin action on fibrinogen complicates the nephrotic state and may be initialed by different mechanisms. It is suggested that this coagulopathy, which remits with clinical improvement, is consequent upon local intrarenal activation of the blood coagulation system.


Related Articles

  • Thrombosis and hemostasis in renal disease.  // Kidney International;Aug1994, Vol. 46 Issue 2, p287 

    Discusses the initiation of normal thrombosis and hemostasis in renal disease. Exposure of subendothelial structures to flowing blood; Formation of solid hemostatic plug; Adhesion of platelets to the site of injury.

  • Renal vein thrombosis in idiopathic membranous glomerulopathy and nephrotic syndrome: Incidence and significance. Wagoner, Richard D.; Stanson, Anthony W.; Holley, Keith E.; Winter, Christine S. // Kidney International;Feb1983, Vol. 23 Issue 2, p368 

    The point prevalence and clinical significance of renal vein thrombosis (RVT) was evaluated in 27 of 33 consecutive nephrotic patients with idiopathic membranous glomerulopathy. A technique of retrograde venography after the injection of epinephrine into the main renal artery lo decrease renal...

  • Cerebral Venous Thrombosis in Patients with Nephrotic Syndrome. Sheng-Feng Sung; Jiann-Shing Jeng; Ping-Keung Yip; Kou-Mau Huang // Angiology;May1999, Vol. 50 Issue 5, p427 

    The authors describe two cases of cerebral venous thrombosis (CVT) in patients with nephrotic syndrome. The main clinical features of CVT were persistent headache, hemiparesis, and seizure, and the diagnosis was based on magnetic resonance imaging and magnetic resonance angiography. Both showed...

  • Uremic bleeding. Deykin, Daniel // Kidney International;Nov1983, Vol. 24 Issue 5, p698 

    Discusses a case of uremic bleeding, a complex disorder of hemostasis, in a 70-year-old man who was admitted for evaluation of chronic renal failure. Clinical characteristics of hemostasis; Role of von Willebrand factor in the formation of a stable platelet plug; Indirect association between the...

  • Nephratic syndrome.  // Pulse;9/27/2004, Vol. 64 Issue 38, p66 

    Presents a case study of nephrotic syndrome in a patient with a history of type 1 diabetes. Medical background of the patient; Complaint of pitting ankle oedema; Complications to watch out for.

  • High Incidence of FSGS in Children.  // Kidney;Nov/Dec99, Vol. 8 Issue 6, p240 

    Focuses on the possible changes in the etiology of childhood nephrosis in a racially mixed urban population. Presence of minimal change nephrotic syndrome in 35 percent of all biopsies and focal segmental glomerulosclerosis (FSGS) in 31 percent; Finding that FSGS is the most common cause of...

  • Red blood cell aggregation in nephrotic syndrome. Ozanne, Patrick; Francis, Robert B.; Meiselman, Herbert J. // Kidney International;Mar1983, Vol. 23 Issue 3, p519 

    Red blood cell (RBC) aggregation induced by fibrinogen is a major determinant of the non-Newtonian flow behavior of human blood and has been suggested as a possible contributing factor for thrombogenesis. Given the elevated fibrinogen levels and the high incidence of thrombotic accidents in...

  • Renal Diseases.  // Kidney International;Dec1979, Vol. 16 Issue 6, p861 

    Discusses abstracts of studies related to renal diseases published as of December 1979. Comparison of age related histology in minimal change nephrotic syndrome; Study about the behavior of anionic charges of podocytes in nephrotic subjects.

  • Lipids and progressive kidney disease. Moorhead, John F. // Kidney International Supplement;Apr1991, Issue 31, pS-35 

    Lipids and progressive kidney disease. The nephrotic syndrome comprises proteinuria, oedema, albuminuria, hypoalbuminaemia, and hyperlipidaemia. Some of its manifestations are present throughout the course of progressive renal disease. Hyperlipidaemia is one of the most dramatic of the clinical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics