TITLE

The role of aluminum in the development of hypercalcemia in the rat

AUTHOR(S)
Rodriguez, Mariano; Felsenfeld, Arnold J.; Llach, Francisco
PUB. DATE
March 1987
SOURCE
Kidney International;Mar1987, Vol. 31 Issue 3, p766
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present study evaluates the effect of an intravenous (i.v.) aluminum infusion on total and ionized calcium. Seven groups of rats were studied, and it was found that the magnitude of hypercalcemia was dose dependent. During a two hour i.v. infusion containing 0.4 mg aluminum per 100 grams of body weight, the total plasma calcium increased from 9.7 ± 0.2 to 12.7 ± 0.7 mg/dl (X ± SE, P < 0.02) while the ionized .calcium decreased from 5.1 ± 0.12 to 4.05 ± 0.2.4 mg/dl (P < 0.001 ). The increase m plasma calcium occurred in intact and parathyroidectomized rats, and the hypercalcemia could not be attributed to changes in PTH. arterial pH, plasma protein, or plasma phosphate, in vitro studies indicate that the addition of aluminum to rat plasma results in decreased ionized calcium concentration. Similarly, ultrafilterable calcium declined from 5.4 ± 0.17 to 4.53 ± 0.12 mg/dl (P < 0.001) after the addition of aluminum to rat plasma. In summary, high levels of intravenous aluminum increase total plasma calcium and decrease ionized calcium. As also supported by in vitro data, the most probable mechanism is increased binding of calcium in the plasma which decreases ionized calcium, As a result of the decreased concentration of ionized calcium, movement of bone and interstitial calcium into the vascular space may occur, thus increasing total plasma calcium.
ACCESSION #
17671419

 

Related Articles

  • Coordinated control of renal Ca2+ transport proteins by parathyroid hormone. van Abel, Monique; Hoenderop, Joost G. J.; van der Kemp, Annemiete W. C. M.; Friedlaender, Michael M.; van Leeuwen, Johannes P. T. M.; Bindels, René J. M. // Kidney International;Oct2005, Vol. 68 Issue 4, p1708 

    Background. The kidney is one of the affected organs involved in the clinical symptoms of parathyroid hormone (PTH)-related disorders, like primary hyperparathyroidism and familial hypocalciuric hypercalcemia. The molecular mechanism(s) underlying alterations in renal Ca2+ handling in these...

  • Is it my calcium, Doctor? Stanley, S.; Shaw, N. J. // Archives of Disease in Childhood -- Education & Practice Edition;Dec2009, Vol. 94 Issue 2, p2 

    The article describes the case of a 12-year old girl diagnosed with hypercalcaemia. Medical history of the patient include collapsing pseudoseizures. Presented are findings from laboratory tests. A brief information on hypercalcaemia is offered. A discussion on how plasma calcium level is...

  • Divalent ion metabolism in patients with acute renal failure: Studies on the mechanism of hypocalcemia. Massry, Shaul G.; Arieff, Allen I.; Coburn, Jack W.; Palmieri, Genaro; Kleeman, Charles R. // Kidney International;Jun1974, Vol. 5 Issue 6, p437 

    Studies were carried out in ten patients with acute renal failure to characterize certain features of deranged divalent ion metabolism. During the oliguric period, the patients displayed hypocalcemia, hyperphosphatemia, hypermagnesemia and elevated levels of immunoreactive parathyroid hormone....

  • Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia. Alon, Uri; VanDeVoorde, René // Pediatric Nephrology;Sep2010, Vol. 25 Issue 9, p1747 

    We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the hypercalcemia seemed to interfere with tissue healing after tympanoplasty. Consequently, he was placed on cinacalcet (30 mg/day), changed after 2 weeks to 60 mg/day. The treatment resulted in a decrease in serum...

  • Sigmoidal relationship between calcitonin and calcium: Studies in normal, parathyroidectomized, and azotemic rats. Torres, Armando; Rodriguez, Mariano; Felsenfeld, Arnold; Martin-Malo, Alejandro; Llach, Fracisco // Kidney International;Oct1991, Vol. 40 Issue 4, p700 

    Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calce- mic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic...

  • Hypomagnesaemic hypocalcaemia in renal failure. Lien, John W.K. // British Medical Journal;11/18/1978, Vol. 2 Issue 6149, p1400 

    Presents a case of hypocalcemia in patients with renal failure. Association between hypocalcemia and parathyroid hormone; Mechanism of hypocalcemia; Cause of delay in the restoration of normocalcemia.

  • Are Phosphatonins Relevant in the Pathogenesis of Nephrolithiasis? Shaikh, Aisha; Kumar, Rajiv // AIP Conference Proceedings;2007, Vol. 900 Issue 1, p170 

    Hypercalciuria is the single most important risk factor for stone disease and renal phosphate excretion is a recognized cause of absorptive hypercalciuria. The recent identification of “phosphatonins” that increase renal phosphate excretion has raised the possibility that these...

  • Parathyroid hormone-mediated aluminum deposition and egress in the rat. Mayor, Gilbert H.; Sprague, Stuart M.; Hourani, Michael R.; Sanchez, Tom V. // Kidney International;Jan1980, Vol. 17 Issue 1, p40 

    Exogenous PTH significantly enhances tissue aluminum concentration in normal rats fed an aluminum-supplemented diet. In this study, we examined the effect of PTH withdrawal on brain and whole carcass aluminum concentrations. Four groups of rats were fed an aluminum diet while receiving...

  • A reduced PTH response to hypocalcemia after a short period of hypercalcemia: A study in dogs. Sánchez, Joaquin; Aguilera-Tejero, Escolastico; Estepa, Jose Carlos; Almadén, Yolanda; Rodríguez, Mariano; Felsenfeld, Arnold J. // Kidney International Supplement;Dec1996, Issue 57, pS-18 

    The relationship between PTH and calcium is best represented as a sigmoidal curve. In the normal animal and human, basal PTM is positioned at approximately 25% of maximal PTM and responds rapidly to small changes in calcium in either direction. Since PTH secretion is designed to respond to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics