Atrial natriuretic peptide in dehydrated Long-Evans rats and Brattleboro rats

Ogawa, Kazuya; Henry, Mark A.; Tange, John; Woodcock, Elizabeth A.; Johnston, Colin I.
March 1987
Kidney International;Mar1987, Vol. 31 Issue 3, p760
Academic Journal
Atrial natriuretic peptide (ANP) was measured by radioimmunoassay in atrial and plasma extracts from normal Long-Evans (LE) rats and Brattleboro-strain diabetes insipidus (DI) rats. LE rats, dehydrated for 72 hours, had an increased plasma osmolality and plasma vasopressin. They also demonstrated a higher atrial immunoreactive ANP (IR-ANP) content than hydrated animals (72 hr dehydration: 178.2 ± 30.4 μg/g wet weight atria, mean ± SE, control: 60.4 ± 8.2; P < 0.001). Plasma IR-ANP in dehydrated LE rats tended to be lower than hydrated LE but this was not statistically significant [72 hr dehydration: 61.9 ± 5.9 pg/ml, control: 82.4 ± 8.2]. IR-ANP concentration in atrial extracts from DI rats, without detectable plasma vasopressin levels but with increased plasma osmolality, was not different from that in hydrated LE rats (DI: 100.6 ± 13.2 μg/g). There was also no significant difference between plasma IR-ANP in DI and hydrated LE rats (DI: 100.2 ± 11.9 pg/mi). The atrial IR-ANP concentration in DI rats was decreased by infusion with either arginine-vasopressin (AVP) or l-deamino-8-arginine vasopressin (DDAVP), and plasma IR-ANP was increased significantly by both infusions (AVP' 171.3 ± 18.1 pg/ml, DDAVP: 179.5 ± 24.6). Thus, changes in atrial and plasma IR-ANP concentration appeared to be associated with changes m water balance but not with plasma AVP levels, indicating that the changes, in volume may be a .more important factor controlling ANP release m vivo than vasopressin itself.


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