Reversing glomerular hypertension stabilizes established glomerular injury

Meyer, Timothy W.; Anderson, Sharon; Rennke, Helmut G.; Brenner, Barry M.
March 1987
Kidney International;Mar1987, Vol. 31 Issue 3, p752
Academic Journal
Munich-Wistar rats were studied 18 weeks following 5⁄6 renal ablation. In untreated group 1 rats maintained on standard chow containing 24% protein, sustained systemic and glomerular hypertension were associated with increasing proteinuria and widespread glomerular injury. In group 2, early treatment with the converting enzyme inhibitor enalapril prevented systemic and glomerular hypertension, and largely limited proteinuria and glomerular injury. Groups 3 and 4 received no therapy during the first eight weeks, during which they developed systemic hypertension and levels of proteinuria previously, shown to be associated with significant glomerular sclerosis at this time point. Enalapril therapy begun at eight weeks in group 3 rats reversed systemic and glomerular hypertension, prevented a further rise in proteinuria, and limited glomerular lesions at 18 weeks relative to group 1. Reduction of dietary protein content to 12% at eight weeks in group 4 rats controlled glomerular but not systemic hypertension to near-normal levels, stabilized proteinuria values, and also limited glomerular lesions at 18 weeks compared to group 1. These studies support the view that glomerular hypertension is an essential hemodynamic derangement responsible for progressive glomerular injury. Furthermore,, reduction of capillary pressure can arrest the progression of remnant glomerular injury even when therapy is delayed until glomerular injury is established.


Related Articles

  • Glomerular hypertension and injury in desoxycorticosterone-salt rats on antihypertensive therapy. Dworkin, Lance D.; Feiner, Helen D.; Randazzo, Joseph // Kidney International;Mar1987, Vol. 31 Issue 3, p718 

    Uninephrectomized male Munich-Wistar rats received either weekly subcutaneous injections of vehicle and water for drinking: rejections of desoxycorticosterone (DOC) and 1% saline (SALT) for drinking; or DOC and SALT with hydrochlorthiazide, hydralazine, reserpine and, KCl added All studies were...

  • Fibrillary glomerulonephritis: An entity with unusual immunofluorescence features. Alpers, Charles E.; Rennke, Helmut G.; Hopper Jr., James; Biava, Claude G. // Kidney International;Mar1987, Vol. 31 Issue 3, p781 

    We describe seven patients with renal biopsy findings of mild glomerular abnormalities on light microscopy but with prominent accumulation of randomly-arranged fibrillar material in the mesangium and capillary walls on electron microscopy. This material differed from amyloid in that fibrils were...

  • The roles of eicosanoids in experimental glomerulonephritis. Rahman, M. A.; Stork, J. E. // Kidney International Supplement;Oct1987, Issue 22, pS-40 

    There is accumulating evidence showing alterations of renal eicosanoid synthesis in glomerular disease. Despite the complexity of their role in glomerulonephritis, these compounds appear to play a major part in the inflammatory response and in control of renal hemodynamics. The role of...

  • Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol. Hamatani, Hiroko; Hiromura, Keiju; Kobatake, Keiko; Yoshida, Hiroaki; Kobayashi, Satsuki; Yoneda, Naohiro; Kayakabe, Ken; Matsumoto, Takayuki; Kuroiwa, Takashi; Ueki, Kazue; Nojima, Yoshihisa // Clinical & Experimental Nephrology;Dec2010, Vol. 14 Issue 6, p619 

    We report two patients, a daughter and a mother, with lipoprotein glomerulopathy (LPG) who were successfully treated with niceritrol. Both patients carried a mutation in the apolipoprotein E (apoE) gene known as ApoE Tokyo/Maebashi. The daughter was found to have proteinuria at the age of 4...

  • HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis. Bakr, Ashraf; Mahmoud, Lotfi Abdel-Naby; Al-Chenawi, Farha; Salah, Amany // Pediatric Nephrology;Mar2007, Vol. 22 Issue 3, p376 

    To investigate the association between HLA-DRB1* alleles and post-streptococcal acute glomerulonephritis (PSAGN) in Egyptian children, 32 unrelated patients with PSAGN and 380 healthy individuals from the same locality were typed for DRB1* alleles using the polymerase chain-reverse hybridization...

  • Rapid and focal loss of negative charge associated with mononuclear cell infiltration early in nephrotoxic serum nephritis. Kreisberg, Jeffrey I.; Wayne, Denise B.; Karnovsky, Morris J. // Kidney International;Sep1978, Vol. 16 Issue 3, p290 

    We have examined the morphologic changes and alterations in negative charge, as demonstrable with colloidal iron at pH 2, in rat glomeruli, 15 min, 0.5, 1, and 2 hours after injecting rabbit antirat kidney serum (NTS). As early as 15 min following NTS administration, mononuclear (MN) cells,...

  • Natural history and treatment of primary proliferative glomerulonephritis: A review. Glassock, Richard J. // Kidney International Supplement;Dec1985, Issue 17, pS136 

    Discussed the aspects of the natural history and treatment of primary proliferative glomerulonephritis. Classification of proliferative glomerulonephritis; Association of severe hypertension with the development of focal and segmental glomerulosclerosis and diffuse interstitial fibrosis;...

  • 303. Prior observations that TGF-β[sub] is involved in glomerular disease are extended. Goumenos, D.S.; Tsakas, S.; Meguid, A. El Nahas // Kidney;May/Jun2003, Vol. 12 Issue 3, p105 

    Objective: To study the site of synthesis and expression profile of TGF-β[sub1] in the renal tissue of patients with heavy proteinuria and examine the relation of this expression with urinary excretion of TGF-β[sub1]. Methodology: Twenty-five patients with heavy proteinuria (8.4 &plusmin;...

  • Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Wyatt, Robert J.; McAdams, A. James; Forristal, Judith; Snyder, Jean; West, Clark D. // Kidney International;Oct1979, Vol. 16 Issue 4, p505 

    Acute poststreptococcal glomerulonephritis (AGN) differed from membranoproliferative glomerulonephritis (MPGN) and lupus nephritis (SLE) in that two of the proteins that control the C3b-dependent convertase. β1H and the C3bC4b-inactivator cofactor (C3bC4blCo), were frequently absent from the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics