TITLE

Glomerular hypertension and injury in desoxycorticosterone-salt rats on antihypertensive therapy

AUTHOR(S)
Dworkin, Lance D.; Feiner, Helen D.; Randazzo, Joseph
PUB. DATE
March 1987
SOURCE
Kidney International;Mar1987, Vol. 31 Issue 3, p718
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Uninephrectomized male Munich-Wistar rats received either weekly subcutaneous injections of vehicle and water for drinking: rejections of desoxycorticosterone (DOC) and 1% saline (SALT) for drinking; or DOC and SALT with hydrochlorthiazide, hydralazine, reserpine and, KCl added All studies were performed six weeks after UNX. At that time, rats receiving DOC and SALT alone were hypertensive and had significantly more proteinuria and morphologic evidence of glomerular injury than rats given vehicle and tap water which were normotensive. Antihypertensive therapy normalized mean arterial pressure in DOC-SALT rats, but failed to prevent proteinuria, mesangial expansion or focal segmental glomerular lesions. Micropuncture studies revealed that glomerular capillary pressure was elevated m both untreated and treated DOC-SALT animals. We conclude that drugs which successfully reduce systemic blood pressure may fail to correct glomerular capillary hypertension in DOC-SALT rats. As persistence of intrarenal hypertension is associated with significant glomerular injury, normalization of glomerular capillary pressure rather than systemic arterial pressure is crucial to the prevention of glomerular injury in this model.
ACCESSION #
17671029

 

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