TITLE

Effects of calcitriol administration on calcium metabolism in healthy men

AUTHOR(S)
Adams, Nancy D.; Gray, Richard W.; Lemann Jr., Jacob; Cheung, Herman S.
PUB. DATE
January 1982
SOURCE
Kidney International;Jan1982, Vol. 21 Issue 1, p90
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Effects of calcitriol administration on calcium metabolism in healthy men. To evaluate the relationship between daily and fasting urinary calcium excretion and serum 1,25(OH)2-D concentrations, we studied six healthy men during control and during chronic oral calcitriol administration (0.6, 1.2, or 1.8 nmoles every 6 hours for 6 to 12 days) while they ate normal and low calcium diets (calcium content, 19.2 or 4.2 mmoles/day). Daily urinary calcium excretion was directly related to serum 1,25-(OH)2-D concentrations but increased more (P < 0.025) while subjects ate the normal calcium diet (slope, 0.081 mmole/day/pmole/liter; r = 0.94) than when eating the low calcium diet (slope, 0.043 mmole/day/pmole/liter; r = 0.83). During calcitriol and ingestion of the low calcium diet, daily urinary calcium excretion averaged 7.32 ± 2.6 mmoles/day, exceeding the dietary calcium intake (P < 0.02). Moreover, during calcitriol, when serum 1,25-(OH)2-D exceeded 140 pmoles/liter, fasting urinary calcium/creatinine exceeded 0.34 mmole/mmole (the upper limit of normal) on either diet. When serum 1,25-(OH)2-D concentrations are elevated, a high fasting urinary calcium/creatinine or high daily urinary calcium excretion, even on a low calcium diet, is insufficient criteria for the documentation of a renal calcium leak.
ACCESSION #
17667430

 

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