TITLE

Circulating vitamin D metabolite concentrations in childhood renal diseases

AUTHOR(S)
Chesney, Russell W.; Hamstra, Alan J.; Mazess, Richard B.; Rose, Philip; DeLuca, Hector F.
PUB. DATE
January 1982
SOURCE
Kidney International;Jan1982, Vol. 21 Issue 1, p65
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Circulating vitamin D metabolite concentrations in childhood renal diseases. Vitamin D metabolites were measured in children, untreated with glucocorticoids, who had renal disease. Two groups were defined in relation to endogenous creatinine clearance values: those with impaired clearance, 0 to 48 ml/min per 1.73 m² and those with unimpaired clearance, 75 to 150 ml/min per 1.73 ². Serum 1,25 (OH)2D was 16 ± (SD) 12 pg/ml in impaired patients (N = 24) and 48 ± 16 pg/ml in unimpaired patients (N = 18). The latter level is not different from healthy childhood controls (43 ± 12 pg/ml; N = 194). Serum samples of 25(OH)D2 and D3 were comparable in each group and not different from control values of 33.2 ± 10.3 ng/ml. Serum 24,25(OH)2D was 0.6 ± (SD) 0.14 ng/ml in patients with a clearance of < ml/min per 1.73 m², 1.39 ± 0.54 ng/ml in those with a clearance of 18 to 48 ml/min per 1.73 m², and 1.52 ± 0.91 ng/ml in patients without an impairment of clearance. Only patients with the lowest clearances had values different from controls values of 1.70 ± 0.57 ng/ml. In our study we suggest that a significant reduction in 24,25(OH)2D and 1,25(OH)2D are found at low clearance values in children with tubulointerstitial disease. Our study further suggests that a reduction in renal tubular mass is important in accounting for these changes in vitamin D metabolite values.
ACCESSION #
17667406

 

Related Articles

  • THE GIFT THAT SAVED MY LIFE. Cates, Tiffanie; Buchholz, Rachel // National Geographic World;Dec2001, Issue 316, p19 

    Relates the experience of student Tiffanie Cates on having a kidney disease in the United States. Information on the disease; How kidneys work; Kidney donor of Cates for her transplant; Life of Cates after the kidney dialysis.

  • Proteinuria and renal disease: prognostic value of urine dipstick testing for leukocytes. Koss, Shira; Perl, Ari; Wieder, Adinah; Frank, Rachel; Vento, Suzanne; Trachtman, Howard // Pediatric Nephrology;Apr2006, Vol. 21 Issue 4, p584 

    Proteinuria is utilized to screen for underlying kidney disease and serves as a marker of disease progression. The aim of this study was to test the hypothesis that patients with proteinuria will have a higher frequency of urine dipstick positive for leukocytes as an index of noninfectious renal...

  • influence of hyperfiltration on the measurement of urinary N-acetyl-β-D-glucosaminidase. Müller, D.; Sievers, E.; Eggert, P. // Pediatric Nephrology;1999, Vol. 13 Issue 6, p519 

    The measurement of urinary enzymes in patients with diabetes mellitus has become a useful additional test for the early detection of nephropathy. Controversy persists concerning methods of measurement since during early stages of insulin-dependent diabetes mellitus children develop the so-called...

  • Levels of urinary transforming growth factor β-1 in children with D+ hemolytic uremic syndrome. Caletti, María; Balestracci, Alejandro; Roy, Adriana // Pediatric Nephrology;Jun2010, Vol. 25 Issue 6, p1177 

    About 25–50% of survivors of the acute phase of postdiarrheal hemolytic uremic syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor β-1 (TGFβ-1) is the main fibrogenic growth factor in humans, and there is a significant correlation between its levels and the...

  • Metabolomics in Adult and Pediatric Nephrology. Fanos, Vassilios; Fanni, Claudia; Ottonello, Giovanni; Noto, Antonio; Dessì, Angelica; Mussap, Michele // Molecules;May2013, Vol. 18 Issue 5, p4844 

    Metabolomics, the latest of the "omics" sciences, has a non-selective approach and can thus lead to the identification of all the metabolites (molecules < 1 kDa) in a biological system. The metabolomic profile can be considered the most predictive phenotype capable of evaluating epigenetic...

  • Intermittent or daily administration of 1-alpha calcidol for nephrectomised infants on peritoneal dialysis? Saarinen, Tuure T.; Arikoski, Pekka; Holmberg, Christer; Rönnholm, Kai // Pediatric Nephrology;Nov2007, Vol. 22 Issue 11, p1931 

    Secondary hyperparathyroidism and renal osteodystrophy are major problems in patients with end-stage renal failure and may result in poor growth in children on dialysis. Whether vitamin D sterols should be given intermittently or daily remains a controversial issue. We studied 16 bilaterally...

  • Effect of vitamin D metabolites on calcitriol degradative enzymes in renal failure. Patel, Sanjeevkumar R.; Hui Qiong Ke; Hsu, Chen H. // Kidney International;Feb1994, Vol. 45 Issue 2, p509 

    We have demonstrated that in renal failure calcitriol degradation is decreased and that administration of vitamin D metabolites increases the degradation. In this study, we measured intestinal 24- and 26-hydroxylase activities and the effects of chronic infusion (7 days) of vitamin D metabolites...

  • Effects of vitamin D metabolites on protein catabolism of muscle from uremic rats. Harter, Herschel R.; Birge, Stanley J.; Martin, Kevin J.; Klahr, Saulo; Karl, Irene E.; Tegtmeyer, Elise; Osborne, Dale F.; Howard, Thomas; Miller, Ruth // Kidney International;Mar1983, Vol. 23 Issue 3, p465 

    Epitrochlearis muscles obtained from normal male Sprague-Dawley rats used as controls (C) and rats with reduced renal mass (Nx) were incubated for 1 hr in Krebs-Ringer buffer containing 5 mM glucose with or without insulin, 25-hydroxycholecalciferol [25(OH)D3] or 1,25 dihydroxycholecalciferol...

  • The effect of cholecalciferol for lowering albuminuria in chronic kidney disease: a prospective controlled study. Molina, Pablo; Górriz, José L.; Molina, Mariola D.; Peris, Ana; Beltrán, Sandra; Kanter, Julia; Escudero, Verónica; Romero, Ramón; Pallardó, Luis M. // Nephrology Dialysis Transplantation;Jan2014, Vol. 29 Issue 1, p97 

    Background Growing evidence indicates that vitamin D receptor activation may have antiproteinuric effects. We aimed to evaluate whether vitamin D supplementation with daily cholecalciferol could reduce albuminuria in proteinuric chronic kidney disease (CKD) patients. Methods This 6-month...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics