TITLE

Transport activity modifies thick ascending limb damage in the isolated perfused kidney

AUTHOR(S)
Brezis, Mayer; Rosen, Seymour; Silva, Patricio; Epstein, Franklin H.
PUB. DATE
January 1984
SOURCE
Kidney International;Jan1984, Vol. 25 Issue 1, p65
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The thick ascending limb of Henle's loop (TAL) develops a specific and consistent structural lesion during perfusion of the isolated rat kidney that progresses from mitochondrial swelling at 15 min to complete cellular disruption at 90 min. Because it seemed possible that damage localized to this metabolically active portion of the nephron might be correlated with cellular transport, the histology of perfused kidneys was examined when transport activity in the TAL was varied. The fraction of TAL tubules showing severe damage (44 ± 2% in kidneys perfused with glucose) was dramatically reduced by furosemide (7 ± 2%; P < 0.001 ). The lesion was eliminated by perfusion with ouabain or by preventing glomerular filtration. On the other hand, protection of TAL cells was not obtained with the proximal diuretic acetazolamide. These results suggest that the lesion of TAL cells that develops during perfusion of the isolated kidney is influenced by the work of cellular transport.
ACCESSION #
17666009

 

Related Articles

  • Effect of cisplatin on the transepithelial potential difference of rat distal tubule. Allen, Glen G.; Barratt, Lindsay J. // Kidney International;Jun1985, Vol. 27 Issue 6, p842 

    Cisplatin, an effective anti-tumor agent, has significant effects on renal function including reduced glomerular filtration rate and potassium and magnesium wasting. It has been shown recently that cisplatin increases sodium conductance across the isolated frog skin, an effect which was...

  • Effect of normal development on compensatory renal growth. Larsson, Lars; Aperia, Anita; Wilton, Patrick // Kidney International;Jul1980, Vol. 18 Issue 1, p29 

    Sprague-Dawley rats were nephrectomized unilaterally or sham-operated al 5, 12, and 40 days of age. The kidney weight, number of glomeruli, GFR, and single nephron GFR (SNGFR) were determined at about 60 days of age. In both sham-operated and nephrectomized rats operated on at 5 and 12 days of...

  • Resetting protects efficiency of tubuloglomerular feedback. Thomson, Scott C.; Vallon, Volker; Blantz, Roland C. // Kidney International Supplement;Sep1998, Issue 67, pS-65 

    Investigates the effect of resetting on tubuloglomerular feedback (TGF). Relation between TGF curve and nephron flow; Events within the juxtaglomerular apparatus causing the TGF curve to reset; Findings on the occurrence of TGF resetting.

  • A simple steady-state model for feedback control of glomerular filtration rate. Briggs, Josephine // Kidney International Supplement;Aug1982, Issue 12, pS-143 

    Repeat measurements of SNGFR during different rates of microperfusion of the loop of Henle have demonstrated that the alterations of SNGFR were greatest between perfusion rates of 10 and 20 nl/min, but that changes also occurred below 10 nl/min and above 20 nl/min. By a simple curve-fitting...

  • Interrelationship between proximal tubular hydrodynamics and tubuloglomerular feedback in the rat kidney. Häberle, Dieter A.; Davis, John M. // Kidney International Supplement;Aug1982, Issue 12, pS-193 

    We have investigated the extent of interaction between the tubuloglomerular feedback mechanism (TGF) and the proximal tubular pressure-mediated changes in glomerular filtration rate (GFR) in hydropenic Wistar rats without interfering with the feedback loop. Infusing or withdrawing tubular fluid...

  • Tubuloglomerular feedback in one-kidney, one-clip hypertensive rats. Ploth, David W.; Mackenzie, Harald S. // Kidney International Supplement;Jun1991, Issue 32, pS-115 

    Previous studies have shown that hydropenic one-kidney, one-clip (1-K,1-C) hypertensive HT rats exhibit impaired auto-regulation of glomerular filtration rate (GFR) in response to reduced arterial perfusion pressure. We investigated the possible role of altered tubuloglomcrular feedback (TGF)...

  • Effect of furosemide administration on glomerular and tubular dynamics in the rat. Tucker, Bryan J.; Blantz, Roland C. // Kidney International;Aug1984, Vol. 26 Issue 2, p112 

    Furosemide, a potent diuretic, has also been shown (1) to inhibit or reduce tubuloglomerular feedback activity, (2) act as a vasodilatory agent, and (3) exhibit a modest carbonic anhydrase inhibitory effect, which could potentially reduce proximal tubule reabsorption. If furosemide can inhibit...

  • Influence of nephron GFR on proximal reabsorption in pentobarbital anesthetized rats. Steven, Kenneth // Kidney International;Mar1974, Vol. 5 Issue 3, p204 

    Imbital uesthettzed rats, Glomerulotubular balance has been defined as the near constant ratio of glomerular filtration rate (GFR) to rate of proximal fluid reabsorption (RPFR). If this is a causal relationship, either GFR or RPFR Is the independent variable. The former hypothesis was evaluated....

  • Effects of intra-animal nephron heterogeneity on studies of glomerular dynamics. Oken, Donald E.; Wolfert, Allen I.; Laveri, Leigh A.; Choi, Sung C. // Kidney International;Jun1985, Vol. 27 Issue 6, p871 

    Quintuplicate determinations of the parameters measured in studies of glomerular dynamics revealed that the intra-animal coefficients of variation for Bowman's space and star vessel pressures, nephron filtration rate, and filtration fractions were 54 to 72% larger than the corresponding...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics