TITLE

Formation and clearance of tubulointerstitial immune complexes in kidneys of rats immunized with heterologous antisera to Tamm-Horsfall protein

AUTHOR(S)
Friedman, Jeffrey; Hoyer, John R.; Seiler, Marcel W.
PUB. DATE
April 1982
SOURCE
Kidney International;Apr1982, Vol. 21 Issue 4, p575
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tubulointerstitial immune complex nephritis was produced by passive immunization of rats with antisera to rat Tamm-Horsfall protein (TH), a surface membrane glycoprotein of the cells of the thick ascending limb of Henle's loop. Circulating anti-TH antibodies were deposited in the kidney after an intravenous injection of rabbit antisera to TH. These anti-TH antibodies combined with TH at the base of tubular cells in the thick ascending limb of Henle's loop and formed granular immune complexes in situ in the space between basal cell surface membranes and tubular basement membranes. Immune complexes were also selectively formed in this site during perfusion of isolated kidneys with antisera to TH. Tubular immune complexes containing immunoglobulin, complement, and TH were maximal during the first week after an intravenous injection while high circulating anti-TH antibody titers were present. As the antibody titers subsequently fell to undetectable levels, tubular immune complexes were rapidly cleared and were virtually absent 4 weeks after the injection. During this clearance phase, rabbit IgG and rat TH were detected in the renal interstitium and in renal hilar lymph nodes. The rapid clearance of subepithelial TH immune complexes contrasts with the prolonged persistance of both glomerular subepithelial immune complexes and basement membrane deposits formed after injection of heterologous antisera to other renal components. The process of rapid clearance of tubulointerstitial immune complexes may allow rapid reversibility of immune injury in tubulointerstitial nephritis.
ACCESSION #
17665377

 

Related Articles

  • Isolation and immunological characterization of human glomerular basement membrane antigens. Marquardt, Hans; Wilson, Curtis B.; Dixon, Frank J. // Kidney International;Jan1973, Vol. 3 Issue 1, p57 

    About 5% of the cases of human glomerulonephritis are mediated by antiglomerular basement membrane (GBM) antibodies produced by the patient and capable of reacting with his own GBM antigen(s). To elucidate the nature of the antigen(s) in human antiGBM nephritis that reacts with antiGBM...

  • Role of a rat membrane inhibitor of complement in anti-basement membrane antibody-induced renal injury. Hatanaka, Yuji; Yuzawa, Yukio; Nishikawa, Kazuhiro; Fukatsu, Atsushi; Okada, Noriko; Okada, Hidechika; Mizuno, Masashi; Matsuo, Seiichi // Kidney International;Dec1995, Vol. 48 Issue 6, p1728 

    In the kidneys of anti-glomerular basement membrane (anti-GBM) antibody disease, binding of antibodies to tubular basement membrane (TBM) is often observed. The present work was performed to explore the mechanisms of binding of anti-GBM antibodies to TBM in vivo with special reference to 5I2Ag,...

  • Desmosomal Antigens Are Not Recognized by the Majority of Pemphigus Autoimmune Sera. Gorbsky, Gary; Cohen, Stephen; Steinberg, Malcolm S. // Journal of Investigative Dermatology;Jun83, Vol. 80 Issue 6, p475 

    Sera from 7 patient with pemphigus vulgaris and both mouse and rabbit antisera against bovine epidermal desmosomes contained antibodies that bound to cell surface components of the spinous layer of bovine epidermis. The antidesmosomal sera show significant binding to purified desmosomal proteins...

  • EXPERIENCE OF THE IMMUNOASSAY CENTER IN THE PRODUCTION OF POLYCLONAL ANTIBODIES FOR IMMUNODIAGNOSIS. Martínez, L.; Vivar, J. R.; Soto, V.; Lorenzo, A.; De Oca, M. Montes; Melchor, A.; Zulueta, O.; Pérez, P.; Valdivia, I.; Cápiro, R.; Hernández, M. L.; Del Sol, R. // Revista VacciMonitor (Vacunología y Temas Afines);Oct2002, Vol. 11 Issue 4, p1 

    The Immunoassay Center owns the necessary technology for the production of the polyclonal antibodies, which guarantees the specificity and sensibility of its diagnostic kits. The main objective of this work is to show the results of the immunization procedures and blood collection methods for...

  • antiserum.  // Royal Society of Medicine: Medicines;2002, p79 

    The article presents information on antiserum. It is a general term used to describe certain preparations of blood serum rich in particular antibodies. Antiserum preparations are used to provide what is called passive immunity to diseases, or some measure of beneficial treatment if the disease...

  • Immunohistochemical localization of two otolith matrix proteins in the otolith and inner ear of the rainbow trout, Oncorhynchus mykiss: comparative aspects between the adult inner ear and embryonic otocysts. Murayama, Emi; Takagi, Yasuaki; Nagasawa, Hiromichi // Histochemistry & Cell Biology;Feb2004, Vol. 121 Issue 2, p155 

    The fish otolith consists mainly of calcium carbonate and organic matrices, the latter of which may play important roles in the process of otolith formation. We previously identified two otolith matrix proteins, named otolith matrix protein-1 (OMP-1) and otolin-1, from the rainbow trout,...

  • Prevalence of Group B Streptococcal Type VI Capsular IgG Antibodies in Japan. Matsubara, K.; Katayama, K.; Baba, K.; Nigami, H.; Harigaya, H. // European Journal of Clinical Microbiology & Infectious Diseases;Jul2003, Vol. 22 Issue 7, p453 

    Investigates the distribution of immunoglobulin G antibodies to serotype VI group B Streptococcus in healthy Japanese patients defined by colonization status. Determination of the type specificity of capsular polysaccharides antigen by the Ouchterlony method using commercially available...

  • Immunohistochemical study of α1-5 chains of type IV collagen in hereditary nephritis. Nakanishi, Koichi; Yoshikawa, Norishige; Iijima, Kazumoto; Kitagawa, Kosaku; Nakamura, Hajime; Ito, Hiroshi; Yoshioka, Kazuo; Kagawa, Megumi; Sado, Yoshikazu // Kidney International;Nov1994, Vol. 46 Issue 5, p1413 

    The distribution of α1-5 chains of type IV collagen [α1-5(1V)] in the glomerular basement membrane (GBM) and epidermal basement membrane (EBM) of 23 families with hereditary nephritis was examined by indirect immunofluorescence. These families were divided into three clinicopathological...

  • SOLUBLE CD59-ANTIGEN LEVELS ARE INCREASED IN RENAL DISEASE PLASMA. Vanderpuye, Oluseyi Adewale // American Journal of Biochemistry & Biotechnology;2013, Vol. 9 Issue 3, p329 

    Cluster of Differentiation antigen 59 (CD59) is a glycosyl phosphatidylinositol-linked protein that protects cells from damage by lytic terminal complexes of complement. Soluble forms of CD59 in serum have been little investigated in disease states. In the present study, by using a sandwich...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics