TITLE

Angiotensins I and II in renal vein blood

AUTHOR(S)
Semple, Peter F.; Cumming, Alison M. M.; Miller, John A.
PUB. DATE
March 1979
SOURCE
Kidney International;Mar1979, Vol. 15 Issue 3, p276
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The concentrations of active renin (PRC), angiotensin I (AI) and angiotensin II (AII) were measured by radioimmunoassay in blood drawn simultaneously and in triplicate from both renal veins and an artery in each of 17 patients with hypertension, 10 of whom had evidence of renal arterial or parenchyma! disease. Plasma concentrations of all three substances were found to be remarkably constant in each of the three samples drawn within 5 min from each site in each patient. In the 6 patients who did not have unilateral renal or renovascular disease, concentrations of renin and AI were (± SEM), respectively, 11 ± 3% and 25 (-14 to + I44)% higher, whereas AII was 16 ± 6% lower, in renal venous plasma than it was in arterial plasma. In the 8 patients with predominantly unilateral renin secretion, concentrations of AI and AII were consistently higher in venous plasma from the affected kidney than they were from the unaffected kidney, whereas the respective mean concentrations of renin, AI, and AII were 4 ± 4%, 7% (-36 to +32)%, and 35 ± 5% lower in venous plasma from the unaffected kidney than they were in arterial plasma. The ratios of the plasma concentrations of AII to renin were lower in renal venous than they were in arterial plasma. Plasma concentrations of AI were closely and similarly related to PRC at all sites. There were highly significant positive correlations between PRC and AI, PRC and AII, and AI and AII, both in arterial and renal venous plasma (r = 0.79 to 0.86, P < 0.001). The present studies thus confirm by direct measurement in vivo the ability of the normal kidney to remove AII from the circulation, and they emphasize the limited capacity fur AII formation within the renal circulation.
ACCESSION #
17661831

 

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