Immunoregulatory factors in the pathogenesis of IgA nephropathy

Emancipator, Steven N.
December 1990
Kidney International;Dec1990, Vol. 38 Issue 6, p1216
Academic Journal
The article presents information on two medical cases related to pathogenesis of IgA nephropathy (IgAN). The first phase of investigation of IgAN consists of a descriptive collation of clinical and/or pathologic features. Nearly all patients with IgAN (95%) have hematuria sometime during the course of the disease. Its severity ranges from episodic macrohematuria (54% of patients), which often is superimposed on persistent microhematuria, to intermittent microhematuria. Proteinuria, the next most frequently observed sign generally is mild: about 50% of patients excrete less than 1 g of protein per day, but proteinuria in excess of 2 g/24 hr occurs commonly, and fully developed nephrosis is encountered in 5% to 10% of patients.


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