TITLE

Hyperkalemia in acute glomerulonephritis due to transient hyporeninemic hypoaldosteronism

AUTHOR(S)
Don, Burl R.; Schambelan, Morris
PUB. DATE
December 1990
SOURCE
Kidney International;Dec1990, Vol. 38 Issue 6, p1159
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Transient hyperkalemia has been reported to occur in patients with acute glomerulonephritis, but the pathogenetic mechanism has not been investigated systematically. We studied the mechanism of hyperkalemia (5.7 to 6.7 mmol/liter) in four men with post-infectious glomerulonephritis. All four patients had clinical findings consistent with acute glomerulonephritis (edema, hypertension, proteinuria, hematuria, and an elevated ASO titer) and a renal biopsy performed in three of the patients confirmed the diagnosis. In comparison to normal subjects (N = 18), plasma aldosterone (5.4 ± 1.6 vs. 22.8 ± 2.6 ng/dl, P < 0.005) and plasma renin activity (0.3 ± 0.2 vs. 4.3 ± 0.6 ng/ml/hr, P < 0.005) were reduced. Hyperkalemia resolved within one to two weeks in two patients as the nephritis resolved and diuresis ensued, and aldosterone and renin levels obtained at follow-up visits were normal. Hyperkalemia persisted despite furosemide-induced diuresis in the other two patients, but resolved with fludrocortisone treatment. Thus, hyperkalemia in patients with acute glomerulonephritis is a manifestation, in part, of hyporeninemic hypoaldosteronism. It is ameliorated by mineralocorticoid therapy and improves spontaneously with resolution of the glomerulonephritis.
ACCESSION #
17656883

 

Related Articles

  • Impact of renin-angiotensin-aldosterone blockade by angiotensin-converting enzyme inhibitors or AT-1 blockers on frequency of contrast medium-induced nephropathy: a post-hoc analysis from the Dialysis-versus-Diuresis (DVD) trial. Kiski, Daniela; Stepper, Wibke; Brand, Eva; Breithardt, Günter; Reinecke, Holger // Nephrology Dialysis Transplantation;Mar2010, Vol. 25 Issue 3, p759 

    Background. After exposure to contrast medium (CM), about 10% of patients will develop contrast medium-induced nephropathy (CIN), with severe consequences for their prognosis. Although numerous studies evaluated risk factors for CIN development, it is still a matter of debate whether treatment...

  • BARTTER'S SYNDROME: AN OVERVIEW. Salomon, Mardoqueo I.; Tchertkoff, Victor // Angiology;Nov1977, Vol. 28 Issue 11, p806 

    Bartter's syndrome, which is characterized by hypokalemic hypochlo-remic alkalosis, renal juxtaglomerular hyperplasia. elevated renin and aldosterone, and normal or low blood pressure, has been ascribed to a variety of etiologies. Most recently, the prostaglandins have been in the forefront of...

  • Renal, cardiovascular and hormonal characteristics of young adults with autosomal dominant polycystic kidney disease. Harrap, Stephen B.; Davies, David L.; Macnicol, Ann M.; Dominiczak, Anna F.; Fraser, Robert; Wright, Alan F.; Watson, Michael L.; Briggs, I. Douglas // Kidney International;Sep1991, Vol. 40 Issue 3, p501 

    We studied young adults with autosomal dominant polycystic kidney disease (ADPKD) to determine the characteristics that precede renal impairment. Nineteen affected (A) and 20 unaffected (U) offspring from families with ADPKD showed no significant differences in basal glomerular filtration rate...

  • Inhibition of angiotensin-converting enzyme modulates structural and functional adaptation to loop diuretic-induced diuresis. Beck, Franz-X.; Ohno, Akihiro; Müller, Eva; Seppi, Thomas; Pfaller, Walter // Kidney International;Jan1997, Vol. 51 Issue 1, p36 

    The roles of elevated cell sodiüm concentrations and the angiotensin-aldosterone system (AAS) in the structural and functional adaptation of the distal tubule and collecting duct system to a chronic increase of sodium delivery were examined using electron microprobe and quantitative...

  • Treatment of Oliguric Glomerulonephritis with Dialysis and Steroids. Nakamoto, Satoru; Dunea, George; Kolff, Willem J.; McCormack, Lawrence J. // Annals of Internal Medicine;Sep65, Vol. 63 Issue 3, p359 

    Describes patients having severe oliguric glomerulonephritis or related nephritic syndromes who were treated by hemodialysis and underwent renal biopsy. Role of the administration of large doses of corticosteroids in producing diuresis; Indications for hemodialysis; Exudation and organization...

  • Abnormal Responsiveness of the Renin Aldosterone System to Acute Stimulation in Patients with Essential Hypertension. Williams, Gordon H.; Rose, Leslie I.; Dluhy, Robert G.; McCaughn, Donald; Jagger, Paul I.; Hickler, Roger B.; Lauler, David P. // Annals of Internal Medicine;Mar70, Vol. 72 Issue 3, p317 

    The responsiveness of the renin aldosterone system to acute stimulation was determined in 16 patients with essential hypertension and 12 normotensive volunteers. All patients were studied under identical metabolic balance conditions with identical stimuli applied. Acute volume depletion, whether...

  • IgA nephropathy.  // Kidney International;Feb1995, Vol. 47 Issue 2, p377 

    The article profides information on various topics related immunoglobulin A nephropathy (IgAN). The main function of the IgA system is to prevent the invasion of the internal milieu. IgAN presents with painless macroscopic hematuria frequently at the time of infectious illnesses. Moreover, the...

  • Routine Immunohistology in Renal Diseases. Lange, K.; Treser, G.; Sagel, I.; Ty, A.; Wasserman, E. // Annals of Internal Medicine;Jan66, Vol. 64 Issue 1, p25 

    Presents a study which examined kidney biopsies on patients with varied renal diseases by the immunofluorescent technique for the presence of gamma globulin, complement and its components. Materials and methods used in the study; Specificity of staining; Differential diagnosis between pure...

  • MYH9 mutation and lupus erythematosus. Elitok, Saban; Göbel, Ursula; Bieringer, Markus; Nagel, Mato; Schneider, Wolfgang; Kettritz, Ralph; Luft, Friedrich C. // NDT Plus;Apr2010, Vol. 3 Issue 2, p128 

    MYH9 is the gene encoding nonmuscle myosin heavy chain IIA. Mutations result in a variety of diverse syndromes that share the association of macrothrombocytopaenia and leukocyte inclusions. Kidney disease may occur. Our patient underwent kidney biopsy in 1970, 1998 and 2008. The biopsies were...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics