TITLE

Effect of leukocyte stimulation on rabbit immune complex glomerulonephritis

AUTHOR(S)
Camussi, Giovanni; Tetta, Ciro; Bussolino, Federico; Turello, Ernesto; Brentjens, Jan; Montrucchio, Giuseppe; Andres, Giuseppe
PUB. DATE
December 1990
SOURCE
Kidney International;Dec1990, Vol. 38 Issue 6, p1047
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Phytohemagglutinin (PHA), a leukocyte mitogen, induces a lymphocyte and blast cell glomerulonephritis in rat renal allografts (Cell Immunol 13:146, 1974). The aim of this study was to assess whether PHA similarly enhances rabbit monocyte-dependent experimental, acute immune complex glomerulonephritis, and whether this effect is associated with local release of interleukin-l (IL-l) and tumor necrosis factor (TNF). Rabbits with experimental acute serum sickness (AcSS: Group I) had focal proliferative and exudative glomerulonephritis with immune deposits, scattered subepithelial electron-dense deposits (humps), mild and transient proteinuria, normal creatinine clearance and slightly increased production of IL-l and TNF from isolated glomeruli. Rabbits with AcSS and injected with PHA (Group II) developed severe lymphocyte and blast cell glomerulonephritis with diffuse endothelial damage; immune deposits were significantly reduced, focal subepithelial electron-dense deposits were absent, proteinuria was increased, creatinine clearance was decreased and production of IL-l and TNF was markedly augmented as compared to rabbits in Group I. Rabbits with AcSS and injected with IL-lβand TNFα (Group V) had lesions comparable to those seen in Group II. These results show that PHA, IL-l and TNF enhance the severity of acute immune complex glomerulonephritis, presumably by activating glomerular endothelial and mesangial cells and resident or infiltrated leukocytes.
ACCESSION #
17656774

 

Related Articles

  • Antibody blockade of TNF-α reduces inflammation and scarring in experimental crescentic glomerulonephritis. Khan, Sarah B.; Cook, H. Terence; Bhangal, Gurjeet; Smith, Jennifer; Tam, Frederick W.K.; Pusey, Charles D. // Kidney International;May2005, Vol. 67 Issue 5, p1812 

    Antibody blockade of TNF-α reduces inflammation and scarring in experimental crescentic glomerulonephritis. Background. Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine produced by macrophages, and by renal mesangial and tubular epithelial cells. It stimulates the release...

  • ¿Osteoinmunología, osteo-reumatología o reumatología sin más? Pérez Esteban, Silvia; Herrero-Beaumont, Gabriel // Reumatologia Clinica;sep/oct2013, Vol. 9 Issue 5, p257 

    No abstract available.

  • Anhedonic and anxiogenic effects of cytokine exposure. Anisman, H.; Merali, Z.; Horning, Mady // Advances in Mind-Body Medicine;Fall2000, Vol. 16 Issue 4, p272 

    Examines the influence of systemic interleukin-1 beta and tumor necrotic factor alpha on central monoamine activity. Impact of cytokine treatments on extrahypothalamic neurochemical functioning; Detection of synergistic effects between cytokines and stressors; Behavioral and neurochemical...

  • Identification of ceramide targets in interleukin-1 and tumor necrosis factor-α signaling in mesangial cells. Pfeilschifter, Josef; Huwiler, Andrea // Kidney International Supplement;Sep1998, Issue 67, pS-34 

    Investigates the identification of ceramide targets in interleukin-1 and tumor necrosis factor-alpha signaling in mesangial cells. Interaction between ceramide and protein kinase c-Raf; Role of ceramide in mediating cellular responses; Characteristics of interleukin-1.

  • Cytokine Networks in the Skin. Schröder, Jens-Michael // Journal of Investigative Dermatology;Jul95 Supplement, Vol. 105, p20S 

    Whereas some cytokines, such as interleukin-1 or tumor necrosis factor-α, have pleiotropic biologic properties, others seem to be more restricted in their biologic behavior. Interleukin-1 and tumor necrosis factor-α are known to induce the tissue accumulation of a mixed leukocyte...

  • Baculovirus Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses After Cell Transplantation. Ching-Kuang Chuang; Tong-Hong Wong; Shiaw-Min Hwang; Yu-Han Chang; Guan-Yu Chen; Yung-Chung Chiu; Shiu-Feng Huang; Yu-Chen Hu // Molecular Therapy;May2009, Vol. 17 Issue 5, p889 

    Baculovirus holds great promise for the genetic modification of mesenchymal stem cells (MSCs). However, whether baculovirus transduction provokes undesired MSCs responses that might compromise their in vivo applications has yet to be examined. Hereby, we unraveled that baculovirus transduction...

  • Adenosine A2A agonists as therapy for glomerulonephritis. Ferenbach, David A.; Hughes, Jeremy // Kidney International;Aug2011, Vol. 80 Issue 4, p329 

    Garcia et al. report the utility of pharmacological activation of the adenosine A2A receptor (A2AR) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A2AR activation in determining outcome...

  • The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. Andersen, Kirstin; Eltrich, Nuru; Lichtnekert, Julia; Anders, Hans-Joachim; Vielhauer, Volker // Kidney International;Nov2014, Vol. 86 Issue 5, p965 

    Interleukin (IL)-1β contributes to renal injury in immune complex glomerulonephritis. However, production of mature IL-1β depends on activation of the inflammasome that cleaves pro-IL-1β into its secretable form. A functional role of the NLRP3-containing inflammasome, which responds to...

  • In situ expression and soluble form of P-selectin in human glomerulonephritis. Segawa, Chikako; Wada, Takashi; Takaeda, Masayoshi; Furuichi, Kengo; Matsuda, Ichirou; Hisaida, Yukimasa; Ohta, Satoshi; Takasawa, Kazuya; Takeda, Shin-ichi; Kobayashi, Ken-ichi; Yokoyama, Hitoshi // Kidney International;Oct1997, Vol. 52 Issue 4, p1054 

    To clarify the early involvement of cellular adhesion molecules in human glomerulonephritis. we investigated P-selectin and high endothelial venules' (HE'Vs) marker MECA-79 expression in kidney specimens by immunohistochemical and in situ hybridization analyses, arid measured serum and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics