TITLE

Clinical profiles and erythrocyte Na&sup+; transport abnormalities of four major types of primary hypertension in Spain

AUTHOR(S)
de la Sierra, Alejandro; Coca, Antonio; Aguilera, María T.; Ingelmo, Miguel; Urbano-Márquez, Alvaro
PUB. DATE
July 1989
SOURCE
Kidney International;Jul1989, Vol. 36 Issue 1, p114
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The interaction of three different Na+ transport systems (Na+-K+ pump, Na+-K+ cotransport and Na+-Li+ countertransport), with internal Na+ and the passive Na+ leaks, were measured in erythrocytes from 72 Spanish, essential hypertensive patients and 30 normotensive controls. According to the observed abnormalities in Na+ transport pathways, 93.1% of the patients were classified into the following subsets: 12 (16.7%) exhibited a decreased apparent affinity of Na+-K+ pump for internal Na+ (Pump ‘-’ hypertensives); 20 (27.7%) showed a decreased apparent affinity of Na+-K+ cotransport for internal Na+ (Co ‘-’ hypertensives): 27 (37.5%) showed an accelerated Na+-Li+ countertransport (Counter ‘+’ hypertensives): and 5 (6.9%) exhibited an increased rate constant of passive Na+ leaks (Leak ‘+’ hypertensives). Finally, 5 patients (6.9%) did not show any abnormality in their Na+ transport systems and 3 exhibited more than one. Moreover, distinctive clinical features were recognized in Co ‘-’ and Counter ‘+’ subsets. Blood pressure values were lower m the former and, conversely, Counter ‘+’ hypertensives showed a higher prevalence of moderate or severe hypertension (65.5% vs. 32.6%: P = 0.0059) and higher values of stimulated plasma renin activity (1.63 ± 0.52 vs. 0.81 ± 0.15: P = 0.0443). Our results confirm the heterogeneity of Na+ transport abnormalities in essential hypertension and suggest that these subsets of hypertensives could represent clinical entities.
ACCESSION #
17654540

 

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