Clinical profiles and erythrocyte Na&sup+; transport abnormalities of four major types of primary hypertension in Spain

de la Sierra, Alejandro; Coca, Antonio; Aguilera, María T.; Ingelmo, Miguel; Urbano-Márquez, Alvaro
July 1989
Kidney International;Jul1989, Vol. 36 Issue 1, p114
Academic Journal
The interaction of three different Na+ transport systems (Na+-K+ pump, Na+-K+ cotransport and Na+-Li+ countertransport), with internal Na+ and the passive Na+ leaks, were measured in erythrocytes from 72 Spanish, essential hypertensive patients and 30 normotensive controls. According to the observed abnormalities in Na+ transport pathways, 93.1% of the patients were classified into the following subsets: 12 (16.7%) exhibited a decreased apparent affinity of Na+-K+ pump for internal Na+ (Pump ‘-’ hypertensives); 20 (27.7%) showed a decreased apparent affinity of Na+-K+ cotransport for internal Na+ (Co ‘-’ hypertensives): 27 (37.5%) showed an accelerated Na+-Li+ countertransport (Counter ‘+’ hypertensives): and 5 (6.9%) exhibited an increased rate constant of passive Na+ leaks (Leak ‘+’ hypertensives). Finally, 5 patients (6.9%) did not show any abnormality in their Na+ transport systems and 3 exhibited more than one. Moreover, distinctive clinical features were recognized in Co ‘-’ and Counter ‘+’ subsets. Blood pressure values were lower m the former and, conversely, Counter ‘+’ hypertensives showed a higher prevalence of moderate or severe hypertension (65.5% vs. 32.6%: P = 0.0059) and higher values of stimulated plasma renin activity (1.63 ± 0.52 vs. 0.81 ± 0.15: P = 0.0443). Our results confirm the heterogeneity of Na+ transport abnormalities in essential hypertension and suggest that these subsets of hypertensives could represent clinical entities.


Related Articles

  • spherocytosis, hereditary. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p705 

    An encyclopedia entry for "hereditary spherocytosis" is presented. It refers to an inherited disorder in which there are a large number of unusually small, round red blood cells in the circulation. The characteristic symptoms of the disorder are tiredness, shortness of breath and jaundice. The...

  • A nationwide population screening program for diabetes in Brazil. Nucci, Luciana B.; Toscano, Cristiana M.; Maia, Ana Lourdes M.; Fonseca, Cláudio D.; Britto, Maria Moema B.; Duncan, Bruce B.; Schmidt, Maria Inês // Revista Panamericana de Salud Publica;Nov2004, Vol. 16 Issue 5, p320 

    Objectives. In 2001, persons throughout Brazil who were 40 years old or older were invited to participate in community screening for diabetes as part of the Brazilian Ministry of Health's Plan for the Reorganization of Care for Arterial Hypertension and Diabetes Mellitus. This report describes...

  • making sense of the new blood pressure guidelines. Martin, Adam // Health (Time Inc. Health);Sep2003, Vol. 17 Issue 7, p65 

    Looks at the changes made to the federal guidelines on prehypertensive people in the U.S. People who are considered prehypertensive; Reason for the changes in the guidelines; Advice for prehypertensive people.

  • NICE signals significant changes in BP guidance.  // Pulse;11/5/2005, Vol. 65 Issue 43, p4 

    Reports on the study which found that the ASCOT trial is likely to have a significant impact on new NICE and British Hypertension Society guidelines for hypertension in Great Britain. Confirmation of the need for a wider evaluation of hypertension guidance; Improvement of the first-line therapy;...

  • Rapid Reduction of Severe Asymptomatic Hypertension: A Prospective, Controlled Trial.  // JAMA: Journal of the American Medical Association;2/23/90, Vol. 263 Issue 8, p1078 

    Discusses the abstract of a research study concerning the rapid reduction of severe asymptomatic hypertension, conducted by Kathleen R. Zeller and colleagues.

  • Training for skeletal muscle capillarization: a Janus-faced role of exercise intensity? Gliemann, Lasse // European Journal of Applied Physiology;Aug2016, Vol. 116 Issue 8, p1443 

    An introduction is presented which discusses various reports published within the issue on topics including exercise pulmonary hypertension, blood circulation disorders and cardiovascular diseases.

  • CIRCULATORY DISORDERS. Funk, Robert E. // Angiology;Dec1953, Vol. 4 Issue 6, p480 

    Discusses the use of Hydergine drug in the treatment of circulatory disorders. Safety profile of the drug; Adverse effects; Toxicity of Hydergine.

  • Treatment and prevention of hypertension: Where have we been and where are we going? Luft, Friedrich C. // Kidney International Supplement;Aug1995, Issue 50, pS-14 

    Explores the modality of treatment and prevention of hypertension. Identification of genes associated with blood pressure regulation and the development of hypertension; Application of diuretics and beta blockers; Influence of environmental factors on blood pressure.

  • Clusters of metabolic risk factors predict cardiovascular events in hypertension with target-organ damage: the LIFE study. de Simone, G.; Olsen, M. H.; Wachtell, K.; Hille, D. A.; Dahlöf, B.; Ibsen, H.; Kjeldsen, S. E.; Lyle, P. A.; Devereux, R. B. // Journal of Human Hypertension;Aug2007, Vol. 21 Issue 8, p625 

    The relation of metabolic syndrome (MetS) with cardiovascular outcome may be less evident when preclinical cardiovascular disease is present. We explored, in a post hoc analysis, whether MetS predicts cardiovascular events in hypertensive patients with electrocardiographic left ventricular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics