Linear IgA Bullous Dermatosis Responsive to a Gluten-Free Diet

Egan, Conleth A.; Smith, Eileen Pazderka; Taylor, Ted B.; Meyer, Laurence J.; Samowitz, Wade S.; Zone, John J.
June 2001
American Journal of Gastroenterology;Jun2001, Vol. 96 Issue 6, p1927
Academic Journal
Dermatitis herpetiformis is associated with a gluten-sensitive enteropathy in >85% of cases. Both the skin lesions and the enteropathy respond to gluten restriction. Linear IgA bullous dermatosis has a much lower prevalence of histological small bowel abnormalities, and lesions are not known to respond to gluten restriction. We report a patient with linear IgA bullous dermatosis and gluten-sensitive enteropathy. This report addresses the issue of whether linear IgA bullous dermatosis can be associated with gluten-sensitive enteropathy. We evaluated the response to gluten restriction and normal diet by following the status of the patient's jejunal biopsies and skin lesions. The patient responded to gluten restriction, as shown by resolution of jejunal abnormalities and skin lesions and subsequently by recurrence of jejunal abnormalities and skin lesions with reinstitution of a gluten-containing diet. This report demonstrates that linear IgA bullous dermatosis can respond to gluten restriction if an underlying gluten-sensitive enteropathy is present.


Related Articles

  • Characterization of the Mucosal Immune Response to Dietary Antigens in Patients with Dermatitis Herpetiformis. Hall, Russell P.; Waldbauer, Gretchen V. // Journal of Investigative Dermatology;May88, Vol. 90 Issue 5, p658 

    The association of dermatitis herpetiformis (DH) with granular IgA deposits at the dermal-epidermal junction and a gluten sensitive enteropathy (GSE) suggests that a mucosal immune response may play an important role in the pathogenesis of DH. The degree of antigenic restriction, the...

  • A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. Marietta, Eric; Black, Kay; Camilleri, Michael; Krause, Patricia; Rogers III, Roy S.; David, Chella; Pittelkow, Mark R.; Murray, Joseph A. // Journal of Clinical Investigation;Oct2004, Vol. 114 Issue 8, p1090 

    Dermatitis herpetiformis (DH) is an autoimmune blistering skin disorder that is associated with gluten sensitivity. It presents as a papulovesicular rash and is often associated with enteropathy. The rash resolves when the patient is placed on a gluten-free diet and/or dapsone. DH, as well as...

  • Dermatitis herpetiformis: effect of gluten-free diet on skin IgA and jejunal structure and function.  // British Medical Journal;4/2/1977, Vol. 1 Issue 6065, p872 

    Examines the effectiveness of gluten-free diet on dermatitis herpetiformis. Deposition of sub-epidermal IgA in unaffected skin; Increase of intraepithelial lymphocytes; Performance of jejunal biopsies, test of bowel function and skin biopsies in patients with dermatitis herpetiformis.

  • Dietary Gluten Challenge Does Not Influence the Levels of Circulating Immune Complexes in Patients with Dermatitis Herpetiformis. Yancey, Kim B.; Cason, Joseph C.; Hall, Russell P.; Lawley, Thomas J. // Journal of Investigative Dermatology;Jun83, Vol. 80 Issue 6, p468 

    To examine the relationship between the gluten-sensitive enteropathy (GSE) and IgA circulating immune complexes (CIC) in dermatitis herpetiformis (DH) a series of dietary gluten-challenge studies were performed in patients with DH and patients with ordinary GSE. Serial serum samples were...

  • Dermatitis herpetiformis and gluten enteropathy: a unifying concept. Feiwel, Michael // Journal of the Royal Society of Medicine;Jan1979, Vol. 72 Issue 1, p2 

    The article cogitates concepts concerning dermatitis herpetiformis and gluten enteropathy. Previous studies associating dermatitis herpetiformis and gluten enteropathy first appeared during the nineteen-sixties or so. However, difficulties remain in correlating the pathogenesis of the two...

  • Small Intestinal Biopsies and HLA Types in Dermatitis Herpetiformis Patients with Granular and Linear IgA Skin Deposits. Lawley, T. J.; Strober, W.; Yaoita, H.; Katz, S. I. // Journal of Investigative Dermatology;Jan1980, Vol. 74 Issue 1, p9 

    In this study we determined whether dermatitis herpetiformis patients whose skin contained linear IgA deposits differ from those whose skin contained granular IgA deposits with regard to the presence of gluten-sensitive enteropathy and with regard to the prevalence of certain histocompatibility...

  • Wheat Protein Antibodies in Dermatitis Herpetiformis. Huff, J. Clark; Weston, William L.; Zirker, Douglas K. // Journal of Investigative Dermatology;Dec79, Vol. 73 Issue 6, p570 

    An enzyme-linked immunosorbent assay was used to detect class-specific antibodies to wheat protein antigens. Antibodies which we detected by this technique reacted indistinguishably with antigens prepared from crude gluten, crude gliadin, alpha-gliadin, Frazer fraction III, and subtraction B and...

  • Soluble Interleukin-2 Receptor Levels in Patients with Dermatitis Herpetiformis. Ward, Michael M.; Pisetsky, David S.; Hall, Russell P. // Journal of Investigative Dermatology;Sep91, Vol. 97 Issue 3, p568 

    To determine the role of T-cell activation in dermatitis herpetiformis (DH), soluble IL-2R levels were measured by enzyme-linked immunosorbent assay (ELISA) in the sera of 30 patients with DH. Levels of this shed receptor are considered to be a measure of in vivo T-lymphocyte actiyation and are...

  • Dermatitis Herpetiformis -- A Disease Associated with Intestinal Malabsorption. Johnson, David P.; Alpert, M. Elliot // American Journal of Gastroenterology;Jan1971, Vol. 55 Issue 1, p21 

    Presents a study on the association of dermatitis herpetiformis with intestinal malabsorption. Details of selecting patients for the research; Results of an intestinal biopsy performed on the subjects; Comments of the investigators.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics