TITLE

Celiac Sprue: Another Autoimmune Syndrome Associated With Hepatitis C

AUTHOR(S)
Fine, Kenneth D.; Ogunji, Frederick; Saloum, Yasser; Beharry, Shari; Crippin, Jeffrey; Weinstein, Jeffrey
PUB. DATE
January 2001
SOURCE
American Journal of Gastroenterology;Jan2001, Vol. 96 Issue 1, p138
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: Celiac sprue is being diagnosed with increasing frequency by screening individuals with epidemiologically associated autoimmune syndromes. We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. METHODS: Two hundred fifty-nine consecutively evaluated patients with chronic hepatitis C infection, 59 with autoimmune liver disease, 137 with other hepatic diseases, 356 with various GI syndromes, and 221 normal volunteers underwent serologic screening for celiac sprue. Patients with antigliadin, antiendomysial, and antitissue transglutaminase antibodies in serum underwent duodenoscopy and biopsy. RESULTS: There was a statistically significantly higher prevalence of antigliadin antibody in all groups of patients with liver disease compared with GI controls and normal controls. However, only patients with hepatitis C (n = 3; 1.2%) or autoimmune liver disease (n = 2; 3.4%) had antiendomysial/antitissue transglutaminase antibody in serum. One of 221 normal volunteers (0.4%) was antigliadin, antiendomysial, and antitissue transglutaminase positive; this individual also was found to have hepatitis C (previously undiagnosed). Each of these six individuals had mild intestinal symptoms, duodenal histopathology consistent with celiac sprue, and the celiac-associated HLA-DQ2 allele. Five of the six followed a prescribed gluten-free diet and experienced symptomatic improvement. CONCLUSION: Celiac sprue is epidemiologically associated with chronic hepatitis C infection and with autoimmune liver disease. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic disease associated with the development of celiac sprue.
ACCESSION #
17635406

 

Related Articles

  • Clinical features of chronic C virus hepatitis in patients with celiac disease. Silano, M.; Volta, U.; Vincentini, O.; De Vincenzi, M. // European Journal of Clinical Microbiology & Infectious Diseases;Oct2009, Vol. 28 Issue 10, p1267 

    The article discusses the relation between celiac disease (CD) liver disorders to patients. It says that 40% of patients with CD have been reported to have mild to moderate hypertransaminasemia at the time of diagnosis of CD. Moreover, CD has been found in about 10% of patients with liver...

  • Peginterferon/ribavirin.  // Reactions Weekly;6/4/2011, Issue 1354, p35 

    The article describes the case of a 42-year-old woman with hepatitis C who developed coeliac disease due to peginterferon and ribavirin treatment.

  • Progress against hepatitis C infection.  // Patient Care;2/15/2002, Vol. 36 Issue 3, p11 

    Describes the progress of therapy against hepatitis C infection as of February 15, 2002. Most common method of detecting hepatitis C virus (HCV) infection; Primary aim for treating HCV infection; Risk factors for HCV infection.

  • Liver Disease in Persons with Asymptomatic Hepatitis C Virus Infection.  // Annals of Internal Medicine;12/17/2002, Vol. 137 Issue 12, pI-36 

    Summarizes the article 'Prevalence of Liver Disease in a Population of Asymptomatic Persons with Hepatitis C Virus Infection,' published in the December 17, 2002 issue of 'Annals of Internal Medicine.' Aim of finding out how often persons with hepatitis virus C infection but no symptoms have...

  • Prevalence of Liver Disease in a Population of Asymptomatic Persons with Hepatitis C Virus Infection. Alberti, Alfredo; Noventa, Franco; Benvegnù, Luisa; Boccato, Silvia; Gatta, Angelo // Annals of Internal Medicine;12/17/2002, Vol. 137 Issue 12, p951 

    Background: The prevalence of significant liver disease in persons with asymptomatic hepatitis C virus (HCV) infection is unclear. Objective: To determine the prevalence and severity of HCV infection in asymptomatic persons. Design: Population-based cross-sectional study. Setting:...

  • Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: a cross sectional and longitudinal study. Wright, M.; Goldin, R.; Fabre, A.; Lloyd, J.; Thomas, H.; Trepo, C.; Pradat, P.; Thursz, M. // Gut;Apr2003, Vol. 52 Issue 4, p574 

    Introduction: The rate of development of liver fibrosis in hepatitis C virus (HCV) infection varies between individuals. This accounts for the variation in duration of progression to cirrhosis. The aims of this study were: (1) to determine whether fibrosis progresses linearly through the grading...

  • Hepatitis C.  // Hepatitis C (National Institute of Allergy/Infectious Disease);2009, p3 

    The article offers information on hepatitis C, which is an infectious disease of the liver.

  • Do you have hepatitis C? Hager, Mary; Reibstein, Larry // Newsweek;5/4/1998, Vol. 131 Issue 18, p83 

    Focuses on incidence in the United States of the viral infection hepatitis C. Estimated number of Americans who have the disease; Identification of groups at risk for the infection; Diagnosis of the disease; Treatment; Living with the disease.

  • UNDERSTANDING HEPATITIS C. Everson, Gregory T. // Share Guide;Sep/Oct2002, Issue 63, p42 

    Provides information about hepatitis C, a liver disease. Epidemiology; Causes, symptoms and treatment; Tests for hepatitis C.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics