Salivary Mucin: A Factor in the Lower Prevalence of Gastroesophageal Reflux Disease in African-Americans?

Rayment, Sean A.; Liu, Bing; Offner, Gwynneth D.; Oppenheim, Frank G.; Troxler, Robert F.
November 2000
American Journal of Gastroenterology;Nov2000, Vol. 95 Issue 11, p3064
Academic Journal
OBJECTIVES: Organic and inorganic constituents of saliva have been implicated as protective components in the esophagus, and deficiencies in one or more of these factors in different races may be an important element in the prevalence of gastroesophageal reflux disease (GERD). To determine whether there are differences in the concentration of salivary mucins between different racial groups, we measured the concentration of mucous glycoprotein MGI and mucous glycoprotein MG2 in whole saliva of African-Americans and Caucasians. METHODS: Whole saliva was collected from 19 African-American (four male, 15 female; mean age 34 yr, range 19-53 yr,) and 25 Caucasian (11 male, 14 female; mean age 31 yr, range 20-51 yr, ) volunteers under masticatory stimulation (1 g Parafilm, 60 strokes/min) between 11:00 AM and 12:00 noon. Total salivary carbohydrate was measured with a periodic acid-Schiff assay and total protein by absorbance at 215 nm. Immunological reagents were employed to quantify MG2 in a combined enzyme-linked immunosorbent assay/enzyme linked lectin assay (ELISA/ELLA) and to quantify MGI in a capture ELISA. RESULTS: The total carbohydrate, protein, MG1 and MG2 values were 24.4 ± 11.9, 243.5 ± 62.7. 21.8 ± 13.4, and n.6 ± 9.5 mg% for African-Americans, and the corresponding values were 23.3 ± 9.3, 221.7 ± 39.7, 25.7 ± 16.2, and 10.9 ± 8.7 mg% for Caucasians. There was no statistical difference for any of the parameters measured between the two groups. Furthermore, it was shown that no correlation existed between salivary flow rate and the concentration of carbohydrate, protein, or salivary mucins in African-Americans and in Caucasians. These results show that flow rate did not influence the measured values for salivary parameters in the two groups. CONCLUSIONS: No differences were found in the concentration of salivary mucins MG1 and MG2 in whole saliva of African-Americans and Caucasians, and it seems unlikely that variations in mucin levels influence the prevalence of GERD in these groups.


Related Articles

  • A NEW PROBABLE INCREASING CAUSE OF ESOPHAGEAL ULCERATION: ALENDRONATE. Colina, Ramon E.; Smith, Milton; Kikendall, James Walter; Wong, Roy K. H. // American Journal of Gastroenterology;Apr1997, Vol. 92 Issue 4, p704 

    We present a case of esophageal ulcerations caused by alendronate (Fosamax), a recently marketed medication. The patient presented with a chief complaint of retrosternal pain and severe odynophagia of 5 days duration. She was taking prednisone 10 mg and azathioprine 100 mg p.o. q.d, for systemic...

  • Prevalence of Helicobacter pylori Seropositivity Among Patients Undergoing Bariatric Surgery: A Preliminary Study. Erim, Tolga; Cruz-Correa, Marcia R.; Szomstein, Samuel; Velis, Evelio; Rosenthal, Raul // World Journal of Surgery;Sep2008, Vol. 32 Issue 9, p2021 

    The objective of this study was to compare the prevalence of Helicobacter pylori (HP) seropositivity in patients undergoing bariatric surgery with that of the general population. H. pylori serologies, tested by ELISA, were collected on 240 morbidly obese patients seen at the Cleveland Clinic...

  • Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease. Jovov, Biljana; Que, Jianwen; Tobey, Nelia A; Djukic, Zorka; Hogan, Brigid L M; Orlando, Roy C // American Journal of Gastroenterology;Jun2011, Vol. 106 Issue 6, p1039 

    OBJECTIVES:An early event in the pathogenesis of gastroesophageal reflux disease (GERD) is an acid-induced increase in junctional (paracellular) permeability in esophageal epithelium (EE). The molecular events that account for this change are unknown. E-cadherin is a junctional protein important...

  • Detection and Quantification Of MUC7 in Submandibular, Sublingual, Palatine, and Labial Saliva by Anti-peptide Antiserum. Bolscher, J. G. M.; Groenink, J.; Van Der Kwaak, J. S.; Van Den Keijbus, P. A. M.; Van't Hof, W.; Veerman, E. C. I.; Nieuw Amerongen, A. V. // Journal of Dental Research;Jul1999, Vol. 78 Issue 7, p1362 

    Abstract. The large carbohydrate moiety of low-Mr salivary mucin MUC7 (originally referred to as MG2) is subject to variations. Biochemical analysis and quantification of MUC7 in saliva samples require recognition tools that are independent of the carbohydrate moiety. Therefore, we have evoked...

  • Glycosylation changes in the salivary glycoproteins of alcohol-dependent patients: a pilot study. Kratz, Ewa M.; Waszkiewicz, Napoleon; Kaluza, Anna; Szajda, Slawomir D.; Zalewska-Szajda, Beata; Szulc, Agata; Zwierz, Krzysztof; Ferens-Sieczkowska, Miroslawa // Alcohol & Alcoholism;Jan/Feb2014, Vol. 49 Issue 1, p23 

    AIM: Glycosylation of serum proteins is affected with prolonged heavy drinking, and carbohydrate deficient transferrin (CDT) is well established and highly specific biomarker of sustained alcohol consumption. However, total amount of sialic acid is not the only glycoepitope that may be altered...

  • Evaluation of an immunoassay kit for the detection of certain organochlorine (cyclodiene) pesticide residues in apple, tomato, and lettuce. Wigfield, Yuk; Grant, Ralph // Bulletin of Environmental Contamination & Toxicology;Sep1992, Vol. 49 Issue 3, p342 

    The article focuses on the results of evaluating a commercially-available enzyme-linked immunosorbent assay (ELISA) kit as a method for residual screening of cyclodiene pesticides in fruits and vegetables. It examines the limits of detection (LODs) and the effects observed when endosulfan in...

  • Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment. Radziejewska, Iwona; Borzym-Kluczyk, Małgorzata; Namiot, Zbigniew; Stefańska, Ewa // Clinical & Experimental Medicine;Jun2011, Vol. 11 Issue 2, p81 

    It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice...

  • PREVALENCE OF HELICOBACTER PYLORI AND CYTOTOXIN-ASSOCIATED GENE A IN IRANIAN PATIENTS WITH NON-EROSIVE AND EROSIVE REFLUX DISEASE. Rasmi, Yousef; Sadreddini, Masoud; Shasavari, Zahra; Raeisi, Sina // Indian Journal of Medical Sciences;Sep2009, Vol. 63 Issue 9, p402 

    BACKGROUND: The prevalence of Helicobacter pylori (H. pylori) infection and its virulent strain (cytotoxin-associated gene A: CagA) has not been evaluated in patients with gastroesophageal reflux disease (GERD) subgroups (erosive and non-erosive) in Iran. AIMS: This study was conducted to...

  • Lectin-like oxidized low density lipoprotein receptor 1(LOX-1) levels and endothelial dysfunction in patients with primary essential hyperhidrosis. Rifaioglu, Emine Nur; Erfan, Gamze; Kaçar, Seval Doğruk; Güzel, Savaş; Alpsoy, Şeref; Kulaç, Mustafa; Karaca, Şemsettin; Şen, Bilge Bülbül; Ekiz, Özlem; Şen, Nihat // Dicle Medical Journal / Dicle Tip Dergisi;2013, Vol. 40 Issue 4, p529 

    Objective: Primary essential hyperhidrosis (PEH) is a disorder characterized by excessive sweating of palms, soles and axilla. Although its etiology was not fully understand, increased activity of the autonomic nervous system may play a role in the pathogenesis of PEH. In the study we aimed to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics