TITLE

Treatment of Small Hepatocellular Carcinoma With Percutaneous Ethanol Injection: A Validated Prognostic Model

AUTHOR(S)
Orlando, Ambrogio; D'Antoni, Adele; Cammà, Calogero; Albanese, Maddalena; Livraghi, Tito; Torzilli, Guido; Virdone, Roberto; Sciarrino, Elio; Simonetti, Rosa Giovanna; Maringhini, Alberto; Pagliaro, Luigi; Cottone, Mario
PUB. DATE
October 2000
SOURCE
American Journal of Gastroenterology;Oct2000, Vol. 95 Issue 10, p2921
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: Percutaneous ethanol injection may prolong the survival of patients with small hepatocellular carcinoma associated with cirrhosis. The aim was to identify prognostic factors of survival and of local recurrence, as well as separate new lesions. METHODS: We performed Cox regression analysis in 115 consecutive patients with hepatocellular carcinoma (81 Child-Pugh class A, 34 Child-Pugh class B) treated by percutaneous ethanol injection. The validity of the model was tested by comparing predicted and observed survival in 105 independent patients from an external series. RESULTS: Overall survival rates were 89%, 63%, and 43% at 1, 2, and 3 yr, respectively. The 1-, 2-, and 3-yr survival rates were 96%, 78%, and 63%, respectively, for Child-Pugh class A patients and were 73%, 35%, 12%, respectively, for Child-Pugh class B. The albumin level was the only independent variable significantly associated with survival (p < 0.0001). The 3-yr rate of appearance of separate new lesions and local recurrence were 41% and 23%, respectively. The survival predicted by the model agreed with that observed in the independent patients. CONCLUSIONS: Survival of patients with hepatocellular carcinoma treated by percutaneous ethanol injection is related to baseline albumin level. The high rate of recurrence (both local and distant) points out the palliative role of this therapy.
ACCESSION #
17624252

 

Related Articles

  • Hepatic Resection for Hepatocellular Carcinoma with Obstructive Jaundice due to Biliary Tumor Thrombi World J. Surg. Vol. 28, No. 5, May 2004. Chun-Nan Yeh; Yi-Yin Jan; Wei-Chen Lee; Miin-Fu Chen // World Journal of Surgery;May2004, Vol. 28 Issue 5, p471 

    ABSTRACT Hepatocellular carcinoma (HCC) with obstructive jaundice due to biliary tumor thrombi is uncommon, and few studies have examined the outcome of hepatectomy for HCC with this unusual entity. This study examined the clinicopathologic factors influencing the outcomes of 17 HCC patients...

  • Comparative Prevalence, Multiplicity, and Progression of Spontaneous and Vinyl Carbamate-Induced Liver Lesions in Five Strains of Male Mice. Takahashi, Kimimasa; Dinse, Gregg E.; Foley, Julie F.; Hardisty, Jerry F.; Maronpot, Robert R. // Toxicologic Pathology;Sep/Oct2002, Vol. 30 Issue 5, p599 

    The overall and age-specific prevalences and multiplicities of spontaneous and chemically induced hepatocellular neoplasia were compared among male B6D2F1, B6C3F1, C3H (C3H/HeNCrl MTV-), B6CF1, and C57BL/6 (C57BL/6NCrl) mice following a single intraperitoneal injection of 0.03 μM vinyl...

  • Towards Tailored Treatment - New Organ-Specific Drug Strategies Interfering in Signal Transduction. Prakash, Jai; de Borst, Martin H. // Current Signal Transduction Therapy;May2011, Vol. 6 Issue 2, p234 

    An introduction is presented in which the editor discusses various reports within the issue on topics including tumor-specific targeting of therapies and targeting of signalling inhibitors to hepatocellular carcinoma.

  • Growth of Hepatocellular Carcinoma into the Right Atrium. Kato, Yasuhiro; Tanaka, Nobuyoshi; Kobayashi, Kenichi; Ikeda, Takayuki; Hattori, Nobu; Nonomura, Akitaka // Annals of Internal Medicine;Oct83, Vol. 99 Issue 4, p472 

    Describes the clinical and pathological findings in five patients with hepatocellular carcinoma who died of intracardiac tumor growth. Symptoms of the primary hepatocellular carcinoma; Information on hepatocellular carcinoma; Description of the sites of the tumor thrombi; Clinical...

  • Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma. Habib, Nagy; Salama, Hosny; Abd El Latif Abu Median, Ahmed; Isac Anis, Ilia; Abd Al Aziz, Rasha Ahmed; Sarraf, Catherine; Mitry, Ragai; Havlik, Roman; Seth, Prem; Hartwigsen, Jack; Bhushan, Reva; Nicholls, Joanna; Jensen, Steen // Cancer Gene Therapy;Mar2002, Vol. 9 Issue 3, p254 

    Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The prognosis of HCC is poor and current therapies are largely ineffective. Genetic abnormalities are commonly seen in HCC tumors particularly with inactivation of the p53 tumor suppressor. Gene therapy with E1B-deleted...

  • Cytokeratin-19 fragments in serum (CYFRA 21-1) as a marker in primary liver cancer. Uenishi, T; Kubo, S; Hirohashi, K; Tanaka, H; Shuto, T; Yamamoto, T; Nishiguchi, S // British Journal of Cancer;6/16/2003, Vol. 88 Issue 12, p1894 

    Using an electrochemiluminescence immunoassay, CYFRA 21-1 concentrations were measured in sera from 187 patients with primary liver cancer (164 with hepatocellular carcinoma (HCC) and 23 with intrahepatic cholangiocarcinoma (ICC)) and 87 patients with benign liver diseases. Concentrations of...

  • CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Matsukura, S; Soejima, H; Nakagawachi, T; Yakushiji, H; Ogawa, A; Fukuhara, M; Miyazaki, K; Nakabeppu, Y; Sekiguchi, M; Mukai, T // British Journal of Cancer;2/24/2003, Vol. 88 Issue 4, p521 

    Inactivations of DNA repair genes, O(6)-methylguanine-DNA methyltransferase (MGMT) and hMLH1, by promoter hypermethylation have been reported in several types of primary human neoplasia. This epigenetic inactivation mechanism remains elusive in hepatocellular carcinoma (HCC). To investigate the...

  • Ultrasonically Guided Percutaneous Ethanol Injection Therapy for Hepatocellular Carcinoma. Seki, Toshihito; Nonaka, Tsuneyuki; Kubota, Yoshitsugu; Mizuno, Takako; Sameshima, Yoshiko // American Journal of Gastroenterology;Nov1989, Vol. 84 Issue 11, p1400 

    Ultrasonically guided percutaneous ethanol injection therapy (US-PEIT) was performed in 26 patients with hepatoceltular carcinomas (HCC) in whom neither surgery nor transcatheter arterial embolization (TAE) was indicated, or TAE had proved ineffective. Comparison of results by various diagnostic...

  • Intra-arterial treatment with Y microspheres for hepatocellular carcinoma: 4 years experience at the Ghent University Hospital. Lambert, Bieke; Sturm, Emiel; Mertens, Jeroen; Oltenfreiter, Ruth; Smeets, Peter; Troisi, Roberto; Vlierberghe, Hans; Defreyne, Luc // European Journal of Nuclear Medicine & Molecular Imaging;Dec2011, Vol. 38 Issue 12, p2117 

    Purpose: We report on our experience in terms of eligibility, safety, response and survival for treatment of hepatocellular carcinoma (HCC) with Y microspheres. Secondly, we investigated the urinary excretion of Y following treatment. Methods: We retrospectively reviewed all HCC patients...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics