TITLE

Interferon: Benefit Beyond Hepatitis Therapy?

AUTHOR(S)
Mallat, Damien B.; El-Serag, Hashem B.
PUB. DATE
December 2001
SOURCE
American Journal of Gastroenterology;Dec2001, Vol. 96 Issue 12, p3435
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In a randomized, controlled trial, 30 hepatitis C virus-infected men who underwent hepatic resection for hepatocellular carcinoma (HCC) were subsequently randomized to receive either interferon a (n = 15) or no interferon (n = 15). Eighty percent of patients had HCV genotype 1b and 20% had genotype 2a. Patients in the treatment group were given interferon a (6 million IU i.m.) daily for 2 wk, then three times weekly for 14 wk, and finally twice weekly for 88 wk. The investigators were blinded to the treatment assignment. The median durations of follow-up were approximately 3 and 2.5 yr for the interferon and control groups, respectively. Three patients (15%) did not complete interferon therapy as a result of side effects. In addition, four patients (20%) with recurrence of HCC had their interferon stopped before the end of the study to allow treatment of the tumor. In the interferon group, two patients had sustained viral response and six had biochemical response. In a survival analysis that included all randomized patients (i.e., intention to treat), recurrent HCC was detected in five patients (30%) in the interferon-a group and in 12 control patients (80%) (p = 0.037). The difference in the rate of HCC between the groups became apparent only after the first 2 yr of follow-up. The authors concluded that interferon-α therapy appears to decrease the recurrence of HCC after resection in patients with chronic hepatitis C infection.
ACCESSION #
17611936

 

Related Articles

  • Infection with hepatitis C virus genotype 4 is associated with a poor response to interferon-alpha. Sherman, Morris; Marinos, George; Sedarati, Farhad; Sherman, M; Marinos, G; Sedarati, F // Annals of Internal Medicine;11/20/2001, Vol. 135 Issue 10, p927 

    Focuses on the response of patients infected with hepatitis C virus genotype 4 to interferon-alpha. Improvement in the initial and sustained virologic response during and after treatment with peginterferon-aplha2a; Normalization of the serum alanine aminotransferase concentrations; Increase of...

  • EASL Roundup.  // BioWorld Today;4/27/2009, Vol. 20 Issue 79, p3 

    The article reports on Phase Ib data from Zymogenetics Inc. and Bristol-Myers Squibb Co. regarding the administration of PEG-interferon lambda in combination with ribavirin in 10 patients. It states that the administration of lambda resulted in a significant reduction in hepatitis C virus (HCV)...

  • Randomized Controlled Trial of Lymphoblastoid Interferon α for Chronic Hepatitis C (Comparison of 9-MU and 6-MU Doses). Yoshioka, Kentaro; Yano, Motoyoshi; Kusakabe, Atsuhiko; Hirofuji, Hideo; Fuji, Akihiko; Kuriki, Junsuke; Arao, Motohiro; Murase, Kenichi; Kidokoro, Ryuichi; Kakumu, Shinichi // American Journal of Gastroenterology;Jan1999, Vol. 94 Issue 1, p164 

    Objective: We conducted a randomized controlled trial to compare the efficacy of two different dosages of lymphoblastoid interferon α (IFN) for the treatment of chronic hepatitis C. Methods: Eighty-four patients with chronic hepatitis C were enrolled and randomly assigned into the two groups;...

  • The "Hit Hard And Hit Earl" Strategy To Treat Chronic Hepatitis C. Barreiros, Ana Paula; Schlaak, Jörg; Gerken, Guido; Galle, PR; Löhr, Hanns // Internet Journal of Gastroenterology;2003, Vol. 2 Issue 2, p22 

    Daily dosed interferon-alpha may prevent mutations of the hepatitis C virus (HCV) quasi-species and may therefore be more efficient in the treatment of chronic hepatitis C than the conventional therapy regimen given three times a week. The drop of viral load in the initial therapy phase has been...

  • Comparative Efficacy of a High or Low Dose of Interferon α2b in Chronic Hepatitis C: A Randomized Controlled Trial. Tassopoulos, Nicolaos C.; Karvountzis, Gerassimos; Touloumi, Giota; Delladetsima, Johana K.; Papatheodoridis, George V.; Katsoulidou, Anta; Retalis, George; Hatzakis, Angelos // American Journal of Gastroenterology;Sep1996, Vol. 91 Issue 9, p1734 

    Objectives: Our objective was to determine the relative efficacy of 6 months of treatment with 10 MU versus 3 MU of interferon-α2b (IFN-α), three times weekly, in chronic hepatitis C (HCV) in a randomized trial. Methods: Ten megaunits of IFN-α were given to 28 patients (group...

  • Low Efficacy of Pegylated Interferon plus Ribavirin plus Nitazoxanide for HCV Genotype 4 and HIV Coinfection. Macías, Juan; López-Cortés, Luis F.; Téllez, Francisco; Recio, Eva; Ojeda-Burgos, Guillermo; Ríos, MªJosé; Rivero-Juárez, Antonio; Delgado, Marcial; Jeremías, Rivas-; Pineda, Juan A. // PLoS ONE;12/7/2015, Vol. 10 Issue 12, p1 

    Background: Nitazoxanide (NTZ) plus pegylated interferon and ribavirin (Peg-IFN/RBV) improved the sustained virological response (SVR) achieved with Peg-IFN/RBV in hepatitis C virus genotype 4 (HCV-4)-monoinfected patients. There are no data currently on the efficacy of Peg-IFN/RBV plus NTZ for...

  • Meta-Analysis of Factors Associated With Sustained Viral Response in Patients on Hemodialysis Treated With Standard or Pegylated Interferon for Hepatitis C Infection. Alavian, Seyed Moayed; Tabatabaei, Seyed Vahid // Iranian Journal of Kidney Diseases;Jul2010, Vol. 4 Issue 3, p181 

    Introduction. The efficacy and safety of pegylated and standard interferon (IFN) have been scrutinized in meta-analyses; however, factors associated with hepatitis C viral response in patients on hemodialysis are not well investigated. Materials and Methods. We evaluated factors that could be...

  • Psychometric evaluation of the hepatitis C virus patient-reported outcomes (HCV-PRO) instrument: validity, responsiveness, and identification of the minimally important difference in a phase 2 clinical trial. Anderson, Roger; Baran, Robert; Erickson, Pennifer; Revicki, Dennis; Dietz, Birgitta; Gooch, Katherine // Quality of Life Research;Apr2014, Vol. 23 Issue 3, p877 

    Purpose: To describe the psychometric properties and identify the minimally important difference (MID) of the hepatitis C virus patient-reported outcomes (HCV-PRO) instrument. Chronic HCV infection and associated treatments negatively affect PROs of function and well-being. Methods: In a phase 2...

  • AASLD Roundup.  // BioWorld Today;11/4/2008, Vol. 19 Issue 215, p5 

    The article reports that Romark Laboratories LC presented data from a Phase II trial using thiazolide nitazoxanide to pretreat hepatitis C virus (HCV) patients prior to adding interferon at the annual meeting of the American Association for the Study of Liver Disease (AASLD) in 2008. 80 percent...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics