The Effect of Sildenafil on Lower Esophageal Sphincter and Body Motility in Normal Male Adults

Rhee, Poong-Lyul; Hyun, Jae Geun; Lee, Jun Haeng; Young-Ho Kim; Hee Jung Son; Kim, Jae J.; Seung Woon Paik; Rhee, Jong Chul; Kyoo Wan Choi
December 2001
American Journal of Gastroenterology;Dec2001, Vol. 96 Issue 12, p3251
Academic Journal
OBJECTIVE: Sildenafil relaxes smooth muscle by blocking type 5 phosphodiesterase, which destroys nitric oxide-stimulated cyclic guanosine monophosphate. The aim of this study is to investigate the change of lower esophageal sphincter (LES) and body motility with the lapse of time after sildenafil infusion in normal male adults. METHODS: After basal esophageal manometry in eight healthy male adult volunteers, we infused a 50-mg tablet of sildenafil dissolved in water in the stomach through the manometry catheter and observed the changes of LES and body motility with the lapse of time. We randomized the study population into two groups, and esophageal manometry was repeated in LES and body .sequence in four volunteers and in body and LES sequence in the other four volunteers immediately after sildenafil infusion. RESULTS: LES resting pressure significantly decreased after sildenafil infusion. The body peristaltic amplitude gradually decreased and eventually disappeared, and the latency increased significantly after sildenafil infusion in both the proximal and distal esophagus. CONCLUSIONS: These data support that nitric oxide mediates LES relaxation and the timing of esophageal peristalsis. In the future, sildenafil can be tried in some esophageal motor disorders, which have defects in nitric oxide neuromuscular communication.


Related Articles

  • Nitric Oxide -- A Major Player in Esophageal Motility. Zayat, Estephan N.; Schuster, Marvin M.; Johnson, David // American Journal of Gastroenterology;Jun2000, Vol. 95 Issue 6, p1584 

    This study evaluated the effect of an infusion of L-NMMA (N-monomethyl-L-Arginine), an inhibitor of nitric oxide synthesis, on 1) esophageal body and lower esophageal sphincter (LES) motility, and 2) gastric distention-triggered transient LES relaxation (TLESR). Thirteen healthy male subjects...

  • Role of macula densa nitric oxide and cGMP in the regulation of tubuloglomerular feedback. Ren, Yilin; Garvin, Jeffrey L.; Carretero, Oscar A. // Kidney International;Nov2000, Vol. 58 Issue 5, p2053 

    Describes the role of macula densa (MD) nitric oxide (NO) in the regulation of tubuloglomerular feedback. Effect of NO on MD; Activation of the guanylate cyclase; Stimulation of the glomerular capillary pressure.

  • Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway. Tahsili-Fahadan, Pouya; Yahyavi-Firouz-Abadi, Noushin; Orandi, Amir Hossein; Esmaeili, Behnaz; Basseda, Zahra; Dehpour, Ahmad Reza // Psychopharmacology;Apr2006, Vol. 185 Issue 2, p201 

    Rationale: Sildenafil citrate is widely prescribed for erectile dysfunction and acts by inhibiting phosphodiesterase type-5, resulting in accumulation of cyclic-guanosine monophosphate (cGMP) via activation of nitric oxide synthase (NOS). The nitric oxide (NO) system is relevant to the rewarding...

  • Viagra: now mending hearts. Mendelsohn, Michael E // Nature Medicine;Feb2005, Vol. 11 Issue 2, p115 

    Reports on the finding that sildenafil (Viagra) can suppress cardiac hypertrophy and improve heart function in mice exposed to chronic pressure overload. Reversal and normalization of pre-established cardiac enlargement due to pressure overload; Role of cyclic guanylic acid (cGMP) for both...

  • Discovery of NO in the penis. Rajfer, J // International Journal of Impotence Research;Sep/Oct2008, Vol. 20 Issue 5, p431 

    In 1989, the recognition by our group at UCLA that nitric oxide was indeed the chemical mediator of penile erection turned out to have major influences on our society and on some of those who participated in this research. Not only did it ultimately lead to the development of drugs like...

  • Modulation of Airway Responsiveness to Acetylcholine by Nitric Oxide in a Rabbit Model. Mensing, T.; Marek, W.; Baur, X. // Lung;1997, Vol. 175 Issue 6, p367 

    Nitric oxide (NO) is an important mediator in the regulation of bronchial muscle tone and airway responsiveness. We investigated the influence of exogenous NO on airway responsiveness to acetylcholine aerosols (ACH) in normal and in hyperresponsive rabbits. White New Zealand rabbits were...

  • Nitric oxide regulated cyclic di-GMP signaling. Boon, Elizabeth M.; Dai, Zhou; Liu, Niu; Henares, Bernadette; Arora, Dhruv; Lahiri, Tanaya // BMC Pharmacology & Toxicology;2013, Vol. 14 Issue Suppl 1, p1 

    An abstract of the article "Nitric oxide regulated cyclic di-GMP signaling" by Elizabeth M. Boon and colleagues, presented at the 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications that was held in Erfurt, Germany from June 28 to 30, 2013 is presented.

  • l-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA. Imagawa, Shigehiko; Tarumoto, Takahisa; Suzuki, Norio; Mukai, Harumi Y; Hasegawa, Yuichi; Higuchi, Masato; Neichi, Tomohiro; Ozawa, Keiya; Yamamoto, Masayuki; Nagasawa, Toshiro // Kidney International;Feb2002, Vol. 61 Issue 2, p396 

    L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA.. Background: N[sup G] -monomethyl-l-arginine (L-NMMA) decreases the expression of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) and increases the expression of GATA-2 mRNA and levels of...

  • Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Chitaley, Kanchan; Wingard, Christopher J.; Clinton Webb, R.; Branam, Heather; Stopper, Vivienne S.; Lewis, Ronald W.; Mills, Thomas M. // Nature Medicine;Jan2001, Vol. 7 Issue 1, p119 

    Relaxation of the smooth muscle cells in the cavernosal arterioles and sinuses results in increased blood flow into the penis, raising corpus cavernosum pressure to culminate in penile erection. Nitric oxide, released from non-adrenergic/non-cholinergic nerves, is considered the principle...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics