TITLE

"Myelodysplasia," Myeloneuropathy, and Copper Deficiency

AUTHOR(S)
Kumar, Neeraj; Elliott, Michaelle A.; Hoyer, James D.; Harper Jr., Charles M.; Ahlskog, J. Eric; Phyliky, Robert L.
PUB. DATE
July 2005
SOURCE
Mayo Clinic Proceedings;Jul2005, Vol. 80 Issue 7, p943
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper deficiency. Prompt and complete reversal of the hematologic abnormalities occurred with copper replacement. Serum copper determination should be included in the work-up of patients with anemia and leucopenia of unclear etiology who have associated myeloneuropathy. The hematologic picture can resemble sideroblastic anemia or myelodysplastic syndrome. Hyperzincemia can be an accompanying abnormality even without exogenous zinc ingestion. The reason for the copper deficiency may not be evident.
ACCESSION #
17600887

 

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