LUNG ALERT: The eosinophil in airway remodelling and hyperresponsiveness in asthma: participant or bystander?

Soth, M.
December 2004
Thorax;Dec2004, Vol. 59 Issue 12, p1051
Academic Journal
The article focuses on the eosinophil in airway remodeling and hyper-responsiveness in asthma. While the presence of eosinophils in asthma has long been recognized, it remains unclear whether they are directly involved in the pathogenesis of asthma or are merely an epiphenomenon. Asthma is a multigenic disease and the importance of eosinophils in the pathogenesis of asthma may vary depending on the rest of the subject's genetic makeup. This could have important therapeutic implications. Targeted suppression of eosinophils may help to attenuate airway remodeling, but may only affect airway hyper-responsiveness in some asthma patients with the right genetic background.


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