TITLE

Supplementary oxygen in healthy subjects and those w!th COPD increases oxidative stress and airway inflammation

AUTHOR(S)
Carpagnano, G. E.; Kharitonov, S. A.; Foschino-Barbaro, M. P.; Resta, O.; Gramiccioni, E.; Barnes, P. J.
PUB. DATE
December 2004
SOURCE
Thorax;Dec2004, Vol. 59 Issue 12, p1016
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Hyperoxia increases oxidative stress through the generation of reactive oxygen species and may therefore enhance inflammation in the lungs. The aim of this study was to investigate whether short term supplementary oxygen (28%) increases oxidative stress and inflammation in the airways by measuring 8-isoprostane and interleukin 6 (IL-6) concentrations in exhaled breath condensate. Methods: Twenty three healthy subjects (12 men, mean (SD) age 48 (7) years) and 23 patients with chronic obstructive pulmonary disease (COPD; 15 men, mean (SD) age 56 (5) years) were studied. 8-isoprostane and IL-6 concentrations were measured by immunoassay. Results: Increased concentrations of 8-isoprostane and 11-6 were found in all subjects alter breathing 28% oxygen for 1 hour. In healthy subjects the concentrations of 8-isoprostane and IL-6 were 10.9(2.9) pg/ml and 4.9 (0.8) pg/mI, respectively, compared with baseline concentrations of 6.1 (1.3) pg/mI and 2.9 (0.6) pg/mI, and in patients with CORD the concentrations were 27.9 (3.1) pg/mI and 8.3 (1.2) pg/mI), respectively, compared with baseline concentrations of 18.9 (3.6) pg/mI and 6.3 (0.6) pg/mI. By contrast, breathing air through the same face mask for 1 hour had no significant effects on 8-isoprostane or IL-6 concentrations in normal subjects or those with COPD. Conclusions: These findings suggest that short term supplementary oxygen may enhance oxidative stress and inflammation in the airways. Whether this happens with long term oxygen therapy needs to be determined.
ACCESSION #
17567365

 

Related Articles

  • Correlation between change in pulmonary function and suppression of reactive nitrogen species production following steroid treatment in COPD. Sugiura, H.; Ichinose, M.; Yamagata, S.; Koarai, A.; Shirato, K.; Hattori, T. // Thorax;Apr2003, Vol. 58 Issue 4, p299 

    Background: Reactive nitrogen species (RNS) have a number of inflammatory actions and the production of these molecules has been reported to be increased in the airways of patients with chronic obstructive pulmonary disease (COPD), which suggests that they may be involved in the inflammatory and...

  • Oxygen.  // Reactions Weekly;5/21/2011, Issue 1352, p29 

    The article describes the case of an 86-year-old woman with chronic obstructive pulmonary disease (COPD) who developed respiratory failure during treatment with oxygen.

  • PENDANT RESERVOIR CANNULA OFFERS ADVANTAGES OVER STANDARD CANNULA IN A MODEL OF COPD.  // Respiratory Care;Oct2014, Vol. 59 Issue 10, pOF27 

    An abstract of the article "Pendant Reservoir Cannula Offers Advantages Over Standard Cannu9la in a Model of COPD" by Sherry Babic and Robert L. Chatburn is presented.

  • PUT YOUR LIPS TOGETHER AND BLOW. RUOCCO, ELENA // Clinical Advisor;Sep2011, Vol. 14 Issue 9, p75 

    In this article, the author discusses how pursed-lip breathing can help patients with chronic obstructive pulmonary disease.

  • Supplemental Oxygen Needs During Sleep. Who Benefits? Owens, Robert L. // Respiratory Care;Jan2013, Vol. 58 Issue 1, p32 

    The physiologic changes that occur in ventilation during sleep contribute to nocturnal oxygen desaturation in those with lung disease. Nocturnal supplemental oxygen is often used as therapy, although convincing data exist only for those who are hypoxemic both during sleep and wake. Ongoing...

  • Oxygen: The Kiss of Life. Nava, Stefano // Respiratory Care;Dec2011, Vol. 56 Issue 12, p1975 

    The article presents the author's insights on the study conducted by Rice and colleagues on the efficiency of two oxygen-conserving device, the AccuO2 and CR-50, for chronic obstructive pulmonary disease (COPD) patients. He says that AccuO2 had better oxygen conservation compared to CR-50. He...

  • High flow oxygen in COPD.  // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;10/30/2010, Vol. 341 Issue 7779, p925 

    The article introduces two papers published within the issue including a study on the use of high flow oxygen in patients with chronic obstructive pulmonary disease (COPD), and an editorial on the study.

  • Coping with Your COPD: Good Advice from a Respiratory Therapist. McCoy, Robert // AARC Times;Jul2013, Vol. 37 Issue 7, p121 

    The article presents answers to questions about managing the use of home oxygen therapy by patients with chronic obstructive pulmonary disease.

  • Patient-Centric LTOT: No Room for Complacency. Dunne, Patrick J.; McCoy, Robert W. // Respiratory Care;Apr2011, Vol. 56 Issue 4, p536 

    The article presents a study which evaluates the accuracy of Vacu-Med 17053 calibrator for ventilation, uptake of oxygen (V&x02D9;O2 and production of carbon dioxide(V&x02D9;CO2. It states that a standard protocol to measure the physiological range of oxygen uptake, carbon dioxide production,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics