LUNG ALERT........: Is Propionibacterium acnes the cause of sarcoidosis?

Mukberjee, S.
November 2004
Thorax;Nov2004, Vol. 59 Issue 11, p942
Academic Journal
This article presents information about a study which reports the induction in mice of pulmonary granulomas, similar to those in sarcoidosis, by indigenous Propionibacterium acnes residing in the lower respiratory tract. This was associated with an influx of P. acnes sensitized CD4+ T lymphocytes from the circulation and, moreover, eradication of P. acnes with antibiotics led to resolution of the granulomas. The study proposes that the immune response against indigenous P. acnes may play a role in the pathogenesis of sarcoidosis, and that antibiotics directed against P. acnes may be a potentially effective treatment in this disease.


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