TITLE

Donepezil did not reduce the rate of institutionalisation or disability in people with mild to moderate Alzheimer's disease

AUTHOR(S)
Standridge, John B.
PUB. DATE
November 2004
SOURCE
Evidence Based Mental Health;Nov2004, Vol. 7 Issue 4, p112
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents an answer to the clinical question related to the effect of donepezil in people with mild to moderate Alzheimer's disease. The superiority, typically in cognition, of donepezil and other cholinesterase inhibitors (ChEls) to placebo has been confirmed in a systematic review. Meta-analysis has shown ChEls to have a modest beneficial impact on neuropsychatric and functional outcomes in patients with mild to moderate Alzheimer's Disease that relative to placebo. Donepezil does not delay time to institutionalization or progression to disability in people with mild to moderate Alzheimer's.
ACCESSION #
17554697

 

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