The art and design of genetic screens: mouse

Kile, Benjamin T.; Hilton, Douglas J.
July 2005
Nature Reviews Genetics;Jul2005, Vol. 6 Issue 7, p557
Academic Journal
Humans are mammals, not bacteria or plants, yeast or nematodes, insects or fish. Mice are also mammals, but unlike gorilla and goat, fox and ferret, giraffe and jackal, they are suited perfectly to the laboratory environment and genetic experimentation. In this review, we will summarize the tools, tricks and techniques for executing forward genetic screens in the mouse and argue that this approach is now accessible to most biologists, rather than being the sole domain of large national facilities and specialized genetics laboratories.


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