TITLE

Protein quality control: knowing when to fold

AUTHOR(S)
Swaminathan, Sowmya
PUB. DATE
July 2005
SOURCE
Nature Cell Biology;Jul2005, Vol. 7 Issue 7, p647
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article cites a study conducted by researcher Judith Frydman published in the June 3, 2005 issue of "Cell" which shows that distinct chaperone pathways control the decision between either folding or degrading cytoplasmic proteins. Misfolded proteins can be refolded or they can be degraded by the ubiquitin-proteasome pathway. Protein chaperones are important for both processes. In the endoplasmic reticulum, two different chaperones sort proteins into folding or degradation pathways. Addressing this question in yeast with a mutant von Hippel-Lindau protein that is folding-defective and unstable.
ACCESSION #
17550413

 

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