Antioxidant defence during cardiopulmonary bypass surgery

Luyten, Chris R.; van Overveld, Frans J.; De Backer, Lieve A.; Sadowska, Anna M.; Rodrigus, Inez E.; De Hert, Stefan G.; De Backer, Wilfried A.
April 2005
European Journal of Cardio-Thoracic Surgery;Apr2005, Vol. 27 Issue 4, p611
Academic Journal
Abstract: Objective: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. Methods: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. Results: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. Conclusion: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage.


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