TITLE

Antioxidant defence during cardiopulmonary bypass surgery

AUTHOR(S)
Luyten, Chris R.; van Overveld, Frans J.; De Backer, Lieve A.; Sadowska, Anna M.; Rodrigus, Inez E.; De Hert, Stefan G.; De Backer, Wilfried A.
PUB. DATE
April 2005
SOURCE
European Journal of Cardio-Thoracic Surgery;Apr2005, Vol. 27 Issue 4, p611
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract: Objective: Cardiac surgery may lead to severe oxidative stress due to formation of oxidation products generated during ischemia and reperfusion. We investigated to which extent oxidative stress influences a number of endogenous antioxidants and markers of cellular activation. Methods: At six time points blood was withdrawn from patients undergoing coronary artery bypass grafting, using the on-pump procedure. Results: Both glutathione peroxidase and superoxide dismutase show a gradual and strong increase in activity during surgery (40 and 30%, respectively), returning to baseline values 24h after surgery. The total antioxidant capacity has a maximum increase of 60%. Markers of cellular activation, such as eosinophil cationic protein and tryptase also increase during the procedure. Conclusion: Cardiac surgery results in systemic inflammation accompanied or caused by severe oxidative stress. The human body has a strong innate oxidative defence screen, which is probably not sufficient to fully compensate for the total amount of oxidative damage.
ACCESSION #
17546188

 

Related Articles

  • Profound haemodilution during normothermic cardiopulmonary bypass influences neither gastrointestinal permeability nor cytokine release in coronary artery bypass graft surgery. Berger, K.; Sander, M.; Spies, C. D.; Weymann, L.; Bühner, S.; Lochs, H.; Wernecke, K.-D.; Von Heymann, C. // BJA: The British Journal of Anaesthesia;Oct2009, Vol. 103 Issue 4, p511 

    Background: Cardiopulmonary bypass (CPB) impairs intestinal barrier function and induces systemic inflammation after cardiac surgery. The objective of this study was to evaluate the effect of profound haemodilution (haematocrit 19–21%) during normothermic CPB on gastrointestinal...

  • Mechanisms of the synthetic inflammatory response. Asimakopoulos, George // Perfusion;1999, Vol. 14 Issue 4, p270 

    Discusses the mechanism of systemic inflammatory response syndrome (SIRS) after cardiopulmonary bypass (CPB). Pulmonary dysfunction after CPB; Effect of cardioplegic myocardial arrest; Activation of Hageman factor.

  • Systemic inflammation and cardiac surgery: an update. Asimakopoulos, G. // Perfusion;Sep2001, Vol. 16 Issue 5, p353 

    Cardiac surgery with cardiopulmonary bypass (CPB) is associated with the development of a systemic inflammatory response that can often lead to dysfunction of major organs. The systemic inflammation can be assessed intra- and postoperatively by measuring concentrations of inflammatory mediators...

  • The effects of various leukocyte filtration strategies in cardiac surgery Warren, Oliver; Alexiou, Christos; Massey, Rachel; Leff, Daniel; Purkayastha, Sanjay; Kinross, James; Darzi, Ara; Athanasiou, Thanos // European Journal of Cardio-Thoracic Surgery;Apr2007, Vol. 31 Issue 4, p665 

    Summary: It is known that cardiopulmonary bypass causes an inflammatory reaction with an associated morbidity and mortality. Several anti-inflammatory strategies have been implemented to reduce this response, including leukocyte removal from the circulation using specialised filters. The aim of...

  • Excessive negative venous line pressures and increased arterial air bubble counts during miniaturized cardiopulmonary bypass: an experimental study comparing miniaturized with conventional perfusion systems. Aboud, Anas; Liebing, Kai; Börgermann, Jochen; Ensminger, Stephan; Zittermann, Armin; Renner, Andre; Hakim-Meibodi, Kavous; Gummert, Jan // European Journal of Cardio-Thoracic Surgery;Jan2014, Vol. 45 Issue 1, p69 

    OBJECTIVES Miniaturized cardiopulmonary bypass (MCPB) is increasingly used in cardiac surgery, because it can lower clinically significant complications such as systemic inflammatory response, haemolysis and high transfusion requirements. A limitation of MCPB is the risk of excessive negative...

  • Inflammatory response in an immunosuppressed patient with Wegener's granulomatosis. Mirsadraee, Saeed; Fraser, Alexander; Kerr, Michael A.; James, Teifi E.; van Doorn, Carin // Perfusion;Mar2004, Vol. 19 Issue 2, p127 

    The use of cardiopulmonary bypass (CPB) triggers a systemic inflammatory response (IR), but it is not known if a similar response occurs in an immuno-suppressed patient with autoimmune disease. In a patient with WG on immunosuppressive therapy the CPB-related IR is reduced.

  • UNDERSTANDING THE INFLAMMATORY RESPONSE TO CARDIAC SURGERY. McGuinness, J.; Bouchier-Hayes, D.; Redmond, J. M. // Surgeon (Edinburgh University Press);Jun2008, Vol. 6 Issue 3, p162 

    The systemic inflammatory response to cardiac surgery is common, and resultant impairment of multiple organ function is generally mild or subclinical due to physiological reserve within organ systems. Unfortunately, the changing profile of patients referred for surgery suggests that the systemic...

  • Preoperative Inhalation of Milrinone Attenuates Inflammation in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass. Gong, Ming; Lin, Xue-Zheng; Lu, Guang-Tao; Zheng, Li-Juan // Medical Principles & Practice;Dec2011, Vol. 21 Issue 1, p30 

    Objectives: The purpose of this study was to evaluate the effect of preoperative inhalation of milrinone on cardiopulmonary bypass (CPB)-related inflammation. Subjects and Methods: A total of 30 patients undergoing cardiac surgery were recruited and randomized for preoperative inhalation of...

  • Cardiopulmonary Bypass during Cardiac Surgery Modulates Systemic Inflammation by Affecting Different Steps of the Leukocyte Recruitment Cascade. Rossaint, Jan; Berger, Christian; Van Aken, Hugo; Scheld, Hans H.; Zahn, Peter K.; Rukosujew, Andreas; Zarbock, Alexander; Schulz, Christian // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Background: It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like...

  • Adjustment of sweep gas flow during cardiopulmonary bypass. Karabulut, Hasan; Toraman, Fevzi; Tarcan, Sümer; Demirhisar, Önder; Alhan, Cem // Perfusion;Sep2002, Vol. 17 Issue 5, p353 

    Cardiopulmonary bypass (CPB) is one of the major tools of cardiac surgery. However, no clear data are available for the ideal value of sweep gas flow to oxygenator during CPB. The aim of this study was to determine the best value for sweep gas flow during CPB. Thirty patients undergoing isolated...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics