TITLE

Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D

AUTHOR(S)
Erhardt, A.; Blondin, D.; Hauck, K.; Sagir, A.; Kohnle, I.; Heintges, I.; Häussinger, D.
PUB. DATE
July 2005
SOURCE
Gut;Jul2005, Vol. 54 Issue 7, p1009
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background an aims: Current interferon alfa (IFN) treatment of chronic hepatitis B has limited efficacy. The role of hepatitis B virus (HBV) genotypes for response to IFN was investigated. Patients and methods: HBV genotype was determined by direct sequencing of the HBV X gene in 165 consecutive patients with chronic replicative hepatitis B treated with standard IFN. HBY genotype A or D was found in 144 cases. Results: Sustained response (six months after treatment) to standard IFN therapy was higher in HBV genotype A compared with HBV genotype D infected patients (49% v 26%; p<0.005). Sustained response to IFN was 46% versus 24% (p<0.03) in hepatitis B e antigen (HBeAg) positive hepatitis (n = 99) and 59% versus 29% (p<0.05) in HBeAg negative hepatitis (n =45) for HBV genotype A compared with HBV genotype D. HBeAg status had no negative impact on IFN response. Multivariate logistic regression identified HBV genotype A and high pretreatment alanine aminotransferase levels (>2 ×upper limit of normal) as independent positive predictive parameters of IFN response. Conclusions: The present study indicates that HBV genotypes A and D are important and independent predictors of IFN responsiveness in chronic hepatitis B. HBV genotype adapted treatment regimens ma)' further improve treatment efficacy in chronic hepatitis B.
ACCESSION #
17496273

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics