Insulin resistance and steatosis in hepatitis C virus infection

Zekry, A.; McHutchison, J. G.; Diehl, A. M.
July 2005
Gut;Jul2005, Vol. 54 Issue 7, p903
Academic Journal
The article discusses insulin resistance (IR) and steatosis in hepatitis C virus (HCV) infection. Steatosis in patients with genotype 1 infection is increasingly recognized as a component of the metabolic syndrome, a condition invariably associated with IR. In support, host factors such as age, body mass index and central obesity have been shown to correlate with the development of steatosis in genotype 1 infected patients. In light of current knowledge of the implications of steatosis and IR in the liver disease, the importance of lifestyle changes need to be an emphasized in treating HCV infected patients.


Related Articles

  • Hepatic steatosis: A benign disease or a silent killer. El-Zayadi, Abdel-Rahman // World Journal of Gastroenterology;7/14/2008, Vol. 14 Issue 26, p4120 

    Steatosis is a common feature of many liver diseases, namely non-alcoholic steatohepatitis (NASH) and hepatitis C virus (HCV) infection, but the pathogenic mechanisms differ. Insulin resistance (IR), a key feature of metabolic syndrome, is crucial for NASH development, associated with many...

  • Hepatitis C Virus, Oxidative Stress and Steatosis: Current Status and Perspectives. González-Gallego, J.; García-Mediavilla, M. V.; Sánchez-Campos, S. // Current Molecular Medicine;Jul2011, Vol. 11 Issue 5, p373 

    Reactive oxygen and nitrogen species (ROS/RNS), whether produced endogenously as a consequence of normal cell functions or derived from external sources, pose a constant threat to cells living in an aerobic environment. When the production of ROS/RNS overrides the antioxidant capability of the...

  • Insulin Resistance in Patients with Chronic Hepatitis C Infection. Abd El-Satar, Hoda; Mahfouz, Mahmoud; Rashed, Layla; Ahmed, Dalia // Australian Journal of Basic & Applied Sciences;2010, Vol. 4 Issue 10, p4554 

    Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. Hepatic steatosis, insulin resistance (IR) and type II diabetes have been observed to occur more frequently in association with HCV infection than other chronic inflammatory liver...

  • Hepatitis C Virus Induces the Cannabinoid Receptor 1. van der Poorten, David; Shahidi, Mahsa; Tay, Enoch; Sesha, Jayshree; Tran, Kayla; McLeod, Duncan; Milliken, Jane S.; Ho, Vikki; Hebbard, Lionel W.; Douglas, Mark W.; George, Jacob // PLoS ONE;2010, Vol. 5 Issue 9, p1 

    Background: Activation of hepatic CB1 receptors (CB1) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB1 expression has not been assessed in patients with chronic hepatitis C (CHC), a disease associated with insulin resistance, steatosis and metabolic...

  • Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4. R Moucari // Gut;Dec2009, Vol. 58 Issue 12, p1662 

    BACKGROUND AND AIMS: Hepatitis C virus (HCV) genotype 4 (HCV-4) is increasing in prevalence in Western countries. However, little is known about the severity of the disease and response to treatment. The aim of this study was to assess the predictors (logistic regression) of severe fibrosis...

  • Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a.  // Virology Journal;2011, Vol. 8 Issue 1, p431 

    The article offers information on the study conducted by the authors related to identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of hepatitis C virus (HCV) genotype 3a. It states that chronic HCV infection results in progressive...

  • Mechanisms of insulin resistance associated with hepatitis C virus infection. Bugianesi, Elisabetta // Hot Topics in Viral Hepatitis;2012, Vol. 8 Issue 24, p13 

    Hepatitis C virus (HCV) infection is able to derange glucose homeostasis already at early stages of infection by inducing insulin resistance (IR). This translates into increased risk of developing overt type 2 diabetes, accelerated liver disease progression toward cirrhosis and hepatocellular...

  • Steatosis and insulin resistance in hepatitis C: A way out for the virus? Del Campo, José A.; Romero-Gómez, Manuel; Méndez-Sánchez, Nahum; Burczynski, Frank J. // World Journal of Gastroenterology;10/28/2009, Vol. 15 Issue 40, p5014 

    The hepatitis C virus (HCV) induces lipid accumulation in vitro and in vivo. The pathogenesis of steatosis is due to both viral and host factors. Viral steatosis is mostly reported in patients with genotype 3a, whereas metabolic steatosis is often associated with genotype 1 and metabolic...

  • Contribution of ultrasonography to the diagnosis of chronic hepatitis C histopathological changes, with emphasis on hepatic steatosis -- Part I. Matsuoka, Marcia Wang; de Oliveira, Ilka Regina Souza; Widman, Azzo; Zanoto, Arnaldo; Kodaira, Sérgio Keidi; Marinho, Leonardo Ellery; Filho, Wilson Jacob; Cerri, Giovanni Guido // Radiologia Brasileira;may/jun2011, Vol. 44 Issue 3, p141 

    Objective: To evaluate the role of ultrasonography in the assessment of histopathological changes in patients with chronic hepatitis C, with emphasis on hepatic steatosis. Materials and Methods: Liver ultrasonography results were compared with histopathological findings of liver biopsy of 192...


Read the Article


Sign out of this library

Other Topics