Probiotics and barrier function in colitis

Gionchetic, P.; Lammers, K. M.; Rizzello, F.; Campieri, M.
July 2005
Gut;Jul2005, Vol. 54 Issue 7, p898
Academic Journal
The article discusses probiotics and barrier function in colitis. There is strong evidence of a role for the indigenous flora in driving inflammatory response in inflammatory bowel disease in genetically predisposed individuals. The exact mechanisms by which probiotics can influence barrier function remain to be elucidated. It is known that certain lactobacilli adhere to mucosal surfaces, inhibit attachment of pathogenic bacteria and enhance secretion of mucins. These properties may be instrumental in improving mucosal barrier function remain to be elucidated.


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