TITLE

Microgravimetric flow analysis of nucleic acid based on adsorption of nanoparticle-bioconjugate

AUTHOR(S)
Mo, Z.-H.; Liang, Y.-L.; Wang, H.-L.; Liu, F.-W.; Xue, Y.-X.
PUB. DATE
June 2005
SOURCE
Analytical & Bioanalytical Chemistry;Jun2005, Vol. 382 Issue 4, p996
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A novel nanoparticle-bioconjugate has been prepared by specific hybridization of the target with complementary thiol-labeled and nanoparticle-labeled probes. The rapid adsorption of the nanoparticle-bioconjugate onto a gold surface via a thiol-gold reaction was monitored in real-time using a quartz crystal microbalance, and used to perform microgravimetric flow analysis of nucleic acid for the first time. This innovative assay is highly reproducible and sensitive, and shows great promise for clinical applications.
ACCESSION #
17434215

 

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