Chirally-functionalized monolithic materials for stereoselective capillary electrochromatography

Lämmerhofer, Michael
June 2005
Analytical & Bioanalytical Chemistry;Jun2005, Vol. 382 Issue 4, p873
Academic Journal
Discusses the versatility of in situ organic polymer monolith approach in terms of flexible adjustment of the surface chemistry. Promotion of the use of tailor-made enantioselective monolithic columns that provide the solutions to specific separation problems; Development of generic post-functionalization concepts to escape from tedious repeated pore structure optimization; Advantages of the organic polymer monolith technology for miniaturized analytical systems as well as their hyphenation with mass spectrometric detection.


Related Articles

  • Chiral separation on a model adsorbent with periodic surface heterogeneity. Szabelski, Paweł; Sholl, David S. // Journal of Chemical Physics;4/14/2007, Vol. 126 Issue 14, p144709 

    Optimization of enantioselectivity in heterogeneous catalysis and chiral chromatography is a challenging task for the production of enantiopure chemicals. Enantioselective adsorbents usually consist of a surface with chiral receptors being either chiral molecules linked to the surface or chiral...

  • Experimental isotherms of HCl on H2O ice under stratospheric conditions: Connections between bulk and interfacial thermodynamics. Henson, B. F.; Wilson, Kevin R.; Robinson, J. M.; Noble, C. A.; Casson, J. L.; Worsnop, D. R. // Journal of Chemical Physics;11/1/2004, Vol. 121 Issue 17, p8486 

    The adsorption of HCl on the surface of H2O ice has been measured at temperatures and pressures relevant to the upper troposphere and lower stratosphere. The measured HCl surface coverage is found to be at least 100 times lower than currently assumed in models of chlorine catalyzed ozone...

  • A Validated Enantioselective Assay for the Determination of Ibuprofen in Human Plasma Using Ultra Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS). Szeitz, András; Edginton, Andrea Nicole; Tao Peng, Henry; Cheung, Bob; Riggs, Kenneth Wayne // American Journal of Analytical Chemistry;Aug2010, Vol. 1 Issue 2, p47 

    A modified ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantitation of ibuprofen enantiomers in human plasma. Ibuprofen and flurbiprofen (internal standard) were extracted from human plasma at acidic pH, using a...

  • Progress in circular dichroism laser mass spectrometry. Logé, Christoph; Bornschlegl, Alexander; Boesl, Ulrich // Analytical & Bioanalytical Chemistry;Nov2009, Vol. 395 Issue 6, p1631 

    Circular dichroism in ion yield has promising new potentials for chiral analysis. Our progress of its development is described here. Circular dichroism in ion yield is achieved by resonance-enhanced multiphoton ionization. The feasibility of circular dichroism spectroscopy and quantitative...

  • Asymmetric additions to dienes catalysed by a dithiophosphoric acid. Shapiro, Nathan D.; Rauniyar, Vivek; Hamilton, Gregory L.; Wu, Jeffrey; Toste, F. Dean // Nature;2/10/2011, Vol. 470 Issue 7333, p245 

    Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals. Although the catalysts developed thus far are remarkably effective at activating...

  • Enantioselective separations by packed column subcritical and supercritical fluid chromatography. Phinney, Karen W. // Analytical & Bioanalytical Chemistry;Jun2005, Vol. 382 Issue 3, p639 

    Enantioselective separations have been one of the most successful applications of supercritical fluid chromatography (SFC). Although analytical scale separations have dominated the literature, the use of SFC for preparative chiral separations is growing. Both analytical and preparative scale SFC...

  • Going Faster, Going Greener with High Efficiency Regis Chiral Stationary Phases in Supercritical Fluid Chiral Chromatography (SFC). Szczerba, Ted; Burger, Terry // LC-GC North America;Sep2011 Supplement, Vol. 29, p18 

    The article focuses on a study that investigates the ability of a RegisCell and RegisPack chiral column to generate fast separations in supercritical fluid chiral chromatography (SFC). It notes that SFC has been regarded as a standard separation support tool for chemical analysis and...

  • Lipases Enantioselectivity Alteration by Immobilization Techniques. Palomo, Jose M. // Current Bioactive Compounds;Aug2008, Vol. 4 Issue 2, p126 

    Lipases are the most used enzymes as biocatalyst in the resolution of chiral compounds. However many times the selectivity towards different intermediates is very low. A simple strategy has recently been reported to permit greatly enhancing the lipase selectivity. The strategy -based on the...

  • Enantiospecific Adsorption of ( R)-3-Methylcyclohexanone on Naturally Chiral Cu(531) R& S Surfaces. Ye Huang; Gellman, Andrew J. // Catalysis Letters;Nov2008, Vol. 125 Issue 3/4, p177 

    The enantiospecific adsorption and desorption of ( R)-3-methylcyclohexanone on naturally chiral Cu(531) R& S surfaces was studied using temperature programmed desorption. The Cu(531) R& S surfaces are of interest because they lie at the center of the stereographic triangle and thus, have the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics