TITLE

Antiarrhythmic Action of β-Blockers: Potential Mechanisms

AUTHOR(S)
Dorian, Paul
PUB. DATE
June 2005
SOURCE
Journal of Cardiovascular Pharmacology & Therapeutics;Jun2005 Supplement, Vol. 10 Issue 2S, pS15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports that multiple direct and indirect mechanisms of adrenergic action on the heart may benefit from the known antiarrhythmic actions of β-blocker therapy and other interventions that decrease sympathetic tone. The blockers in the heart are responsible for the primary direct effects of adrenergic activation on atrial and ventricular tissue. Adrenergic stimulation has complex and varied effects on integrated cardiac electrophysiologic properties. In the presence of myocardial ischemia. sympathetic activation leads to shortened action potential duration and cardiac refractoriness and increased conduction velocity in the heart as well as heterogeneity of cardiac electrophysiologic properties.
ACCESSION #
17407661

 

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