A new class of antimycobacterial drugs: the diarylquinolines

Samson, I.
June 2005
Thorax;Jun2005, Vol. 60 Issue 6, p492
Academic Journal
The article presents information about R207910, a diarylquinoline drug. The drug acts as an inhibitor of mycobacterial ATP synthase, a different mechanism of action from any other anti-TB drug. It is specific in activity to mycobacteria, including the opportunistic species, with in vivo bactericidal activity against M tuberculosis in a murine model. Animal and human pharmacokinetic and pharmacodynamic studies showed that R207910 has a long plasma half life, good tissue penetration, and potential for a dose regimen of less than five doses per week, making it ideal for DOT.


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