Lymphatic vessels as targets for intervention in the treatment of inflammatory airway diseases

Quint, J.
June 2005
Thorax;Jun2005, Vol. 60 Issue 6, p487
Academic Journal
The article discusses factors triggering lymphangiogenesis in response to increased leakage in airway inflammation. Researchers used mouse models with chronic respiratory tract infections with Mycoplasma pulmonis and models with adenoviral transduction of airway epithelium with VEGF family growth factors. In pathogen free mice, blood and lymphatic vessels form discrete segmented networks. Treatment with antibodies against VEGFR-1 or VEGFR-2 had no effect on growth of lymphatic vessels after M pulmonis infection.


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