A Prospective Study of Gastric Emptying and Its Relationship to the Development of Nausea, Vomiting, and Anorexia after Autologous Stem Cell Transplantation

DiBaise, John K.; Lyden, Elizabeth; Tarantolo, Stefano R.; Bierman, Philip J.; Brand, Randall E.
July 2005
American Journal of Gastroenterology;Jul2005, Vol. 100 Issue 7, p1571
Academic Journal
BACKGROUND AND AIMS : Gastric motor dysfunction may be responsible, in some patients, for the nausea and emesis that occur following high-dose chemotherapy (HDT) and autologous stem cell transplantation (SCT). We sought to define the prevalence of gastric emptying abnormalities and their relationship to the development of nausea, vomiting, and anorexia in patients undergoing HDT and autologous SCT. METHODS : We prospectively studied patients with a variety of malignancies who received standard transplantation doses of chemotherapeutic agents and antiemetics. Gastric emptying was assessed prior to HDT and on Days 0 (day of stem cell infusion), +7, and +14 from SCT. Symptom assessment was obtained daily from initiation of HDT to 28 days after SCT. RESULTS : Twenty-four patients were studied. Prior to HDT, gastric emptying was rapid in two patients. Nausea, emesis, and anorexia occurred in all patients, peaked in severity at Day +7 after SCT and, with the exception of anorexia, had returned toward baseline levels by Day +28. As a group, gastric emptying was significantly slower on Days 0 and +7 and returned to baseline level by Day +14. Twenty-six percent and 44% of patients demonstrated delayed gastric emptying (T1/2 >90 min) on Days 0 and +7, respectively, while 13% and 31% of patients had rapid gastric emptying (T1/2 <30 min) on Days 0 and +7, respectively. Thirty-nine percent and 75% of patients had either rapid or delayed gastric emptying on Days 0 and +7, respectively. There was an association between delayed gastric emptying and moderate-severe anorexia on Day +7 and between delayed gastric emptying and at least mild vomiting on Day 0. Additionally, there was an association between rapid gastric emptying and at least mild vomiting on Day +7. Finally, an association was found between either rapid or delayed gastric emptying and at least mild nausea on Day +7. CONCLUSION : Both delayed and rapid gastric emptying occur commonly during the 2-wk period following HDT and autologous SCT and may be responsible, at least in part, for upper gastrointestinal symptoms that occur in these patients. (Am J Gastroenterol 2005;100:1571–1577)


Related Articles

  • Predictive factors for survival in myeloma patients who undergo autologous stem cell transplantation: a single-centre experience in 211 patients. O'Shea, D.; Giles, C.; Terpos, E.; Perz, J.; Politou, M.; Sana, V.; Naresh, K.; Lampert, I.; Samson, D.; Narat, S.; Kanfer, E.; Olavarria, E.; Apperley, J. F.; Rahemtulla, A. // Bone Marrow Transplantation;Apr2006, Vol. 37 Issue 8, p731 

    High-dose therapy with autologous stem cell therapy (ASCT) has become the treatment of choice for eligible patients with myeloma. We analysed retrospectively the prognostic influence of pre-transplant characteristics and transplant modalities on response and survival in 211 myeloma patients who...

  • Effects of Embryonic Neural Stem Cell Transplantation on DNA Damage in the Brain and Spinal Cord Following Spinal Cord Injury. Dagci, T.; Konyalioglu, S.; Keser, A.; Kayalioglu, G. // Neurophysiology;Dec2009, Vol. 41 Issue 6, p409 

    Embryonic neural stem cell (ENSC) transplantation is used experimentally for the improvement of spinal cord repair following spinal cord injury (SCI). However, the effects of such intervention on oxidative stress and cell death remain unknown. We used in vivo Comet assay in the acute and chronic...

  • Hematopoietic stem cell transplantation.  // Genes & Immunity;Apr2005 Supplement, Vol. 6, pS70 

    The article reports that HLA matching plays a major role in determining the outcome of a hematopoietic stem cell transplantation (HSCT). An optimal donor for an allogeneic HSCT is a genotypically HLA-identical sibling of a patient. If the patient has no siblings, an extended family typing may...

  • Prophylactic defibrotide in allogeneic stem cell transplantation: minimal morbidity and zero mortality from veno-occlusive disease. Dignan, F.; Gujral, D.; Ethell, M.; Evans, S.; Treleaven, J.; Morgan, G.; Potter, M. // Bone Marrow Transplantation;Jul2007, Vol. 40 Issue 1, p79 

    Veno-occlusive disease (VOD) is a common and high-risk complication of allogeneic stem cell transplantation (SCT). Defibrotide has recently been used successfully to treat the disorder. We report on 58 patients who received defibrotide prophylaxis without concurrent heparin. No patients...

  • Liver Stem Cells and Possible Clinical Applications. Carloni, Guido; Ponzetto, Antonio; Marchese, Rodolfo; Brunetti, Ercole; Crema, Annalisa // Current Stem Cell Research & Therapy;Dec2010, Vol. 5 Issue 4, p314 

    The discovery of several sources of hepatic progenitors in extra-hepatic organs and tissues, both in animal models and in humans, supports opportunities to isolate, grow and expand them in vitro. Microenvironment factors involved in regulating proliferation and commitment of liver cell...

  • Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa. Wagner, John E.; Ishida-Yamamoto, Akemi; McGrath, John A.; Hordinsky, Maria; Keene, Douglas R.; Riddle, Megan J.; Osborn, Mark J.; Lund, Troy; Dolan, Michelle; Blazar, Bruce R.; Tolar, Jakub // New England Journal of Medicine;8/12/2010, Vol. 363 Issue 7, p629 

    Background: Recessive dystrophic epidermolysis bullosa is an incurable, often fatal mucocutaneous blistering disease caused by mutations in COL7A1, the gene encoding type VII collagen (C7). On the basis of preclinical data showing biochemical correction and prolonged survival in col7-/- mice, we...

  • Alzheimer's Disease and Neural Transplantation as Prospective Cell Therapy. Oliveira Jr., Alcyr A.; Hodges, Helen M. // Current Alzheimer Research;Jan2005, Vol. 2 Issue 1, p79 

    It has long been recognised that Alzheimer's disease (AD) patients present an irreversible decline of cognitive functions as consequence of cell deterioration in the forebrain cholinergic projection system (FCPS), particularly, in a structure called nucleus basalis of Meynert (nbM). The...

  • Acute renal failure in hematopoietic cell transplantation. Parikh, C. R.; Coca, S. G. // Kidney International;Feb2006, Vol. 69 Issue 3, p430 

    Hematopoietic cell transplantation is a common procedure for the treatment of malignancies and some non-malignant hematologic disorders. In addition to other transplant-related organ toxicities, acute renal failure is a common complication following transplantation. This review discusses the...

  • Stem Cell Therapy for Myelin Diseases. Ben-Hur, Tamir; Einstein, Ofira; Bulte, Jeff W.M. // Current Drug Targets;Feb2005, Vol. 6 Issue 1, p3 

    Advances in cell biology have encouraged the hope that stem cell-based therapy can be used to heal central nervous system (CNS) diseases. Here, we will review the potential application of neural cell transplantation for the treatment of multiple sclerosis (MS) and other demyelinating disorders,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics