TITLE

Long-term Trends in Thyroid Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 1935-1999

AUTHOR(S)
Burke, James P.; Hay, Ian D.; Dignan, Fiona; Goellner, John R.; Achenbach, Sara J.; Oberg, Ann L.; Melton, III, L. Joseph
PUB. DATE
June 2005
SOURCE
Mayo Clinic Proceedings;Jun2005, Vol. 80 Issue 6, p753
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To determine whether there was a significant increase in the incidence of thyroid carcinoma in Olmsted County, Minnesota, that may be attributed to the widespread use of therapeutic head and neck irradiation between 1920 and the 1950s or to exposure to atomic fallout at the Nevada Test Site in the 1960s. METHODS: Rochester Epidemiology Project resources were used to identify potential cases of thyroid carcinoma among residents of Olmsted County between 1935 and 1984. We extended this earlier study through 1999. RESULTS; During the study period, thyroid carcinoma was newly diagnosed in 263 residents, in women, the age-adjusted incidence increased from 2.7 per 100,000 person years (p-y) in 1935-1949 to 9.2 per 100,000 p-y in 1990-1999 (P=.001); in men, the rate increased from 0.8 to 5.0 per 100,000 p-y (P=.007). However, most of the increase occurred before 1965 and remained relatively stable thereafter. Similar trends were observed for papillary carcinoma alone. CONCLUSION: Although the incidence of thyroid carcinoma increased significantly between 1935 and 1964, no significant increases have been seen since 1965, suggesting that neither atmospheric atomic fallout from the Nevada Test Site nor use of ionizing radiation to treat conditions of the head and neck significantly affected the incidence of thyroid carcinoma in Olmsted County.
ACCESSION #
17340593

 

Related Articles

  • Age-Period-Cohort Analysis of Thyroid Cancer Incidence in Korea. Chang-Mo Oh; Kyu-Won Jung; Young-Joo Won; Aesun Shin; Hyun-Joo Kong; Jin-Soo Lee // Cancer Research & Treatment;2015, Vol. 47 Issue 3, p362 

    Purpose: South Korea has the highest incidence rate of thyroid cancer in the world, and the incidence rate continues to increase. The aim of this study was to determine the age-period-cohort effects on the incidence of thyroid cancer in Korea. Materials and Methods: Using the Korean National...

  • Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis. Mizuno, T; Kyoizumi, S; Suzuki, T; Iwamoto, K S; Seyama, T // Oncogene;9/18/97, Vol. 15 Issue 12, p1455 

    Ionizing radiation is a well-known risk factor of cancer development, but the mechanism of radiation induced carcinogenesis is not clear. Chromosomal rearrangements induced by radiation most likely are one of the principal genetic alterations resulting in malignant transformation. The chimeric...

  • PKC δ mediates ionizing radiation-induced activation of c-Jun NH2-terminal kinase through MKK7 in human thyroid cells. Mitsutake, Norisato; Namba, Hiroyuki; Shklyaev, Stanislav S; Tsukazaki, Tomoo; Ohtsuru, Akira; Ohba, Motoi; Kuroki, Toshio; Ayabe, Hiroyoshi; Yamashita, Shunichi // Oncogene;2/22/2001, Vol. 20 Issue 8, p989 

    The thyroid gland is one of the most sensitive organs in ionizing radiation (IR)-induced carcinogenesis. To determine, therefore, the specific cascade of IR-induced signal transduction in human thyroid cells, we investigated the functional role of protein kinase C (PKC), especially its...

  • The carcinogenic effect of exposure to low doses of carcinogens Tubiana, M. // British Journal of Industrial Medicine;Sep1992, Vol. 49 Issue 9, p601 

    No abstract available.

  • EXPOSURE ASSESSMENT: IMPLICATIONS FOR EPIDEMIOLOGICAL STUDIES OF IONIZING RADIATION. Muirhead, Colin R. // Radiation Protection Dosimetry;Special Issue 2008, Vol. 132 Issue 2, p134 

    Quantitative estimates of ionizing radiation exposure are often available for use in epidemiological studies. However, depending on the context, the quality of the exposure estimates can vary. For example, the estimates may be specific to individuals in the study or generic values averaged over...

  • EXPOSURE ASSESSMENT AND OTHER CHALLENGES IN NON-IONIZING RADIATION STUDIES OF CHILDHOOD LEUKAEMIA. Kheifets, L.; Oksuzyan, S. // Radiation Protection Dosimetry;Special Issue 2008, Vol. 132 Issue 2, p139 

    Studies of electromagnetic fields (EMF) and the development of childhood leukaemia face unique difficulties. EMF are imperceptible, ubiquitous, have multiple sources, and can vary greatly over time and distances. Childhood leukaemia and high average exposures to magnetic fields are both quite...

  • Evaluating Positron Emission Tomography Use in Differentiated Thyroid Cancer. Wiebel, Jaime L.; Esfandiari, Nazanene H.; Papaleontiou, Maria; Worden, Francis P.; Haymart, Megan R. // Thyroid;Sep2015, Vol. 25 Issue 9, p1026 

    Background: Using the Surveillance, Epidemiology, and End Results-Medicare database, a substantial increase was found in the use of positron emission tomography (PET) scans after 2004 in differentiated thyroid cancer (DTC) patients. The reason for the increased utilization of the PET scan was...

  • Epidemiological studies of ionizing radiation and cancer: Past successes and future challenges. Samet, Jonathan M. // Environmental Health Perspectives Supplements;Jun97 Supplement 4, Vol. 105, p883 

    Examines epidemiologic studies on the relationship between ionizing radiation and cancer. Health risks of ionizing radiation; Challenges for understanding risks of ionizing radiation; Cancer incidence among those exposed to ionizing radiation.

  • Choosing Populations to Study the Health Effects Of Low-Dose Ionizing Radiation. Dreyer, Nancy A.; Loughlin, Jeanne E.; Friedlander, Emily R.; Clapp, Richard W.; Fahey, Frederic H. // American Journal of Public Health;Nov81, Vol. 71 Issue 11, p1247 

    In January 1978, the United Stales Congress requested information about the utility of additional epidemiologic studies for quantifying the health effects of low-dose ionizing radiation. In our judgment, no single population can be recommended for study on purely scientific grounds, since the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics