TITLE

Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the normal human endometrium through the menstrual cycle

AUTHOR(S)
Taylor, Anthony; Guzail, Muna; Wahab, May; Thompson, John; Al-Azzawi, Farook
PUB. DATE
April 2005
SOURCE
Histochemistry & Cell Biology;Apr2005, Vol. 123 Issue 4/5, p463
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to test the hypothesis that the distribution of oestrogen receptor beta (ERβ) and androgen receptor (AR) are related to cell proliferation or correlated with the expression of progesterone receptor (PR) or oestrogen receptor alpha (ERα) in the normal human endometrium. Immunohistochemical distribution of immunoreactive ERβ in well-characterised menstrual cycle biopsy samples was lowest in proliferative endometrial glands, highest in early secretory phase glands and maintained at ~20% throughout the rest of the menstrual cycle and was closely correlated with stromal AR and stromal ERβ expression. Stromal ERβ was not significantly altered until the menstrual phase of the cycle and was not correlated with the expression of any other antigen in the stroma or endometrial glands except stromal AR. By contrast, glandular AR immunoreactivity was below 5% early in the cycle, increased during the secretory phase and showed strong expression just before menstruation. PR and Ki-67 expression showed strong positive correlations, indicating that PR may be a potent regulator of endometrial proliferation. These data suggest that glandular ERβ expression is closely associated with a functional secretory role whereas glandular ERα and PR are associated with proliferation; glandular AR expression may be the switch required for menstruation.
ACCESSION #
17332444

 

Related Articles

  • Expression of Transcription Factors in Endometrium During Natural Cycles. Maldonado, Vicente; Castilla, José Antonio; Martínez, Luis; Herruzo, Alfonso; Concha, Ángel; Fontes, Juan; Mendoza, Nicolás; García-Peña, María Luisa; Mendoza, José Luis; Magán, Rosa; Ortiz, Águeda; González, Esther // Journal of Assisted Reproduction & Genetics;Nov2003, Vol. 20 Issue 11, p474 

    Purpose: The sex steroid control of the endometrial cycle is mediated by transcription factors, four of which are the estrogen and progesterone receptors, c-jun and c-fos, all expressed by the endometrium. The aim of this study was to analyze the distribution of the transcription factors in the...

  • Molecular events in the endometrium. Oestrogen receptor α and β mRNA expression in human endometrium throughout the menstrual cycle. Matsuzaki, Sachiko; Fukaya, Takao; Suzuki, Takashi; Murakami, Takashi; Sasano, Hironobu; Yajima, Akira // MHR: Basic Science of Reproductive Medicine;Jun99, Vol. 5 Issue 6, p559 

    We examined the localization of oestrogen receptor (ER) β mRNA in the human endometrium throughout the menstrual cycle using non-radioactive in-situ hybridization with Brigati-tailed oligonucleotides. The findings were compared with those of ERα in order to examine the possible biological...

  • DNA ploidy may be a prognostic marker in stage I and II serous adenocarcinoma of the endometrium. Pradhan, Manohar; Davidson, Ben; Abeler, Vera; Danielsen, Håvard; Tropé, Claes; Kristensen, Gunnar; Risberg, Björn // Virchows Archiv;Sep2012, Vol. 461 Issue 3, p291 

    In patients with serous adenocarcinoma (SAC) of the endometrium, we evaluated the prognostic importance of clinicopathological parameters, DNA ploidy, and immunoexpression of p53, estrogen receptor (ER), progesterone receptor (PR), and Ki-67. In a series of 73 stage I and II SAC, DNA ploidy...

  • The effects of tamoxifen on proliferation and steroid receptor expression in postmenopausal endometrium. Mourits, M.J.E.; Ten Hoor, K.A.; van der Zee, A.G.J.; Willemse, P.H.B.; de Vries, E.G.E.; Hollema, H. // Journal of Clinical Pathology;Jul2002, Vol. 55 Issue 7, p514 

    Aim: To study the effects of tamoxifen on the proliferation index and oestrogen receptor (ER) and progesterone receptor (PR) expression in postmenopausal endometrium. Methods: A total of 125 endometrial specimens of postmenopausal women, comprising benign endometria from tamoxifen users (n = 35)...

  • Endometrial progesterone resistance and PCOS. Xin Li; Yi Feng; Jin-Fang Lin; Håkan Billig; Ruijin Shao // Journal of Biomedical Science;2014, Vol. 21 Issue 1, p1 

    Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasia and carcinoma. A key contributor to our understanding of progesterone as a critical...

  • The effect of intrauterine levonorgestrel use on the expression of c-JUN, oestrogen receptors, progesterone receptors and Ki-67 in human endometrium. Salmi, A; Salmi, A.; Pakarinen, P; Pakarinen, P.; Peltola, AM; Peltola, A.-M.; Rutanen, EM; Rutanen, E.-M. // MHR: Basic Science of Reproductive Medicine;Dec98, Vol. 4 Issue 12, p1110 

    Studies the effect of intrauterine levonorgestrel use on the expression of c-JUN, estrogen receptors, progesterone receptors and K167 in human endometrium. Behavior and role of estrogen and progesterone in the endometrial function; Role of the interactions between steroid receptors and...

  • Cycle-dependent expression of macrophage migration inhibitory factor in the human endometrium. R. Kats; M. Al-Akoum; S. Guay; C. Metz; A. Akoum // Human Reproduction;Dec2005, Vol. 20 Issue 12, p3518 

    BACKGROUND: Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine that was shown to promote angiogenesis and tissue remodelling. Our previous studies identified MIF as one of the principal bioactive molecules involved in endothelial cell proliferation released by ectopic...

  • Estudio Histomorfológico Comparativo del Endometrio de Ovejas Prepúberes de Razas de Distinta Prolificidad. Vasconcellos, Adriana C.; Carrasco, Johannna R.; Valdés, Fernando F. // International Journal of Morphology;2008, Vol. 26 Issue 1, p143 

    The aim of the present study was to sit morphological bases for the inmumocitochemical and hybridazion in situ study of the presence and distribution of estrogen and progesterone receptors in sheep of different prolificity and in different nutrition plane, centering our interest in the...

  • Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle. Vincent Bombail; Sheila MacPherson; Hilary O.D. Critchley; Philippa T.K. Saunders // Human Reproduction;Dec2008, Vol. 23 Issue 12, p2782 

    : BACKGROUND Estrogen receptor related beta (ERRβ, ESRRB/NR3B2) is an orphan receptor that shares significant sequence homology with estrogen receptors ERα and ERβ. ERR family members are reported to exhibit constitutive transcriptional activity; however, little is known about the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics