Stem cells: The road not taken

Hock, Hanno; Orkin, Stuart H.
June 2005
Nature;6/2/2005, Vol. 435 Issue 7042, p573
Academic Journal
This article presents information related to haematopoietic stem cells (HSCs). These cells reside in bone marrow and are the source of the various blood-cell types. The classic experiments of I.L. Weissman showed that HSCs give rise to progenitor populations that can be isolated prospectively by using antibodies against cellsurface proteins. Analysis of different progenitor populations suggested a simple hierarchy with progressively restricted developmental potential. The result is an alphabet soup of progenitor cells-the common lymphoid progenitors, common myeloid progenitors, megakaryocyte/erythrocyte progenitors and the granulocyte/monocyte progenitors.


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