TITLE

Stem cells: The road not taken

AUTHOR(S)
Hock, Hanno; Orkin, Stuart H.
PUB. DATE
June 2005
SOURCE
Nature;6/2/2005, Vol. 435 Issue 7042, p573
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents information related to haematopoietic stem cells (HSCs). These cells reside in bone marrow and are the source of the various blood-cell types. The classic experiments of I.L. Weissman showed that HSCs give rise to progenitor populations that can be isolated prospectively by using antibodies against cellsurface proteins. Analysis of different progenitor populations suggested a simple hierarchy with progressively restricted developmental potential. The result is an alphabet soup of progenitor cells-the common lymphoid progenitors, common myeloid progenitors, megakaryocyte/erythrocyte progenitors and the granulocyte/monocyte progenitors.
ACCESSION #
17230931

 

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