Zussman, William V.
December 1967
Angiology;Dec1967, Vol. 18 Issue 12, p741
Academic Journal
The kidneys of rats previously subject to partial unilateral renal artery ligation were studied to evaluate the activity of the renal innervation in experimentally induced hypertension. Alteration? of adrenergic innervation were examined from 3 to 90 days following operation utilizing a specific histochemical fluorescence technique. The distribution and quantity of fluorescent material closely paralleled the phases of hypercellularity, distortion, thickening and hyalinization of capillary tufts. The fine glomerular fibers first observed became progressively thicker and irregular and finally were replaced by aggregates of dense flourescent material surrounded by coarse fibers. A juxtaglomerular plexus of fine and coarse fluorescent fibers was oriented about the afferent arteriole and proximal convoluted tubule. The disease process causing the other manifestations of hypertension in the experimental rats was probably also responsible for the altered catecholamine storage. This permitted fluorescent visualization of glomerular fibers not observed with previous techniques, suggesting an effect of enhanced adrenergic stimulation.


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