TITLE

HEMODYNAMIC RESPONSES OF SELECTIVE CORONARY ARTERIOGRAPHY IN DOGS

AUTHOR(S)
Corliss, Robert J.; McKenna, David H.; Sialer, Salvador; Rowe, George G.
PUB. DATE
December 1967
SOURCE
Angiology;Dec1967, Vol. 18 Issue 12, p734
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Injection of sodium and meglumine diatrizoates and sodium iothalamate into the left coronary arteries in the anesthetized dog was evaluated. Sodium and meglumine diatrizoates produced a slight but significant increase in the cardiac output for the first 2 minutes following the injection. Sodium iothalamate tended to decrease the cardiac output for approximately the first minute. There was no significant change in the pulmonary or femoral arterial pressures. There were generally a few seconds of bradycardia followed by a relative tachycardia of about 10 seconds with intracoronary injection of either contrast material. Injections of the sodium and meglumine diatrizoates then produced a slight bradycardia while the sodium iothalamate injections caused a mild tachycardia. T-wave inversion increased for about 30 seconds with either agent. Ventricular fibrillation occurred twice following intracoronary injections of sodium iothalamate but did not occur in this series following .similar injections of sodium and meglumine diatrizoates. Sodium and meglumine diatrizoates have less adverse effects than sodium iothalamate when used as the contrast agent for selective coronary arteriography in dogs.
ACCESSION #
17228651

 

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