Testosterone measurements in early infancy

Tomlinson, C.; Macintyre, H.; Dorrian, C. A.; Ahmed, S. F.; Wallace, A. M.
November 2004
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Nov2004, Vol. 89 Issue 6, pF558
Academic Journal
Circulating testosterone concentrations in infants measured by a direct chemiluminescent immunoassay (Bayer ADVIA Centaur) were compared with those measured by a traditional radioimmunoassay using solvent extraction. The results confirm that neonatal circulating testosterone concentrations are method dependent, and each laboratory should establish method related reference ranges especially if using a direct commercial immunoassay. The results indicate that the Bayer ADVIA Centaur procedure can be used reliably in neonates. Expected values for male and female infants < 10 days old were 2.5-11.1 (n = 36) and 1.7-5.6 (n = 36) nmol/l respectively. For older neonates (10- 50 days) the ranges were 0.2-1 7.2 (n = 42) and 0.1-1.5 (n = 7) nmol/l respectively.


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