Pearce, J. M. S.
November 2004
Journal of Neurology, Neurosurgery & Psychiatry;Nov2004, Vol. 75 Issue 11, p1552
Academic Journal
The article focuses on the history of poliomyelitis research. During the first decade of twentieth century treatment and prevention were of little avail and epidemics continued with a large toll of residual disabilities. In 1935 Maurice Brodie had attempted to modify the virus by exposing it to formaldehyde. This formalin inactivated "vaccine" was first tried with 20 monkeys, then with 3000 children. The results were poor and Brodie's vaccine wasnever used again. Attempts to develop a polio vaccine progressed. In 1955, J.E. Salks developed the inactivated poliovirus vaccine; thus began widespread immunisation.


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