Cadaver Renal Transplantation in Children

Tejani, Amir; Fine, Richard N.
April 1993
Clinical Pediatrics;Apr1993, Vol. 32 Issue 4, p194
Academic Journal
In North America, about 50% of all renal transplants done in children are from a living-related donor source — a figure two and a half times greater than the comparative figure for Europe. Graft survival in children is lower for cadaveric donor (CD) than for living-related donor (LRD) kidneys. Four of 10 children with a CD kidney lose their graft within four years. Since it is unlikely that the availability of LRD kidneys will increase, attention must be focused on improving outcome of cadaver renal transplants in children. This review analyzes factors that affect graft outcome. Young recipient age, utilization of kidneys from very young donors, and cold ischemia time are detrimental to prolonged graft survival. Additional factors that impact adversely on cadaver graft survival are a history of previous transplantation, absence of a DR match, and black ethnic origin of the recipient. An understanding of risk factors to graft survival should enable physicians to optimize cadaver renal transplantation in children.


Related Articles

  • Renal transplantation using non-heart-beating donors: a potential solution to the organ donor shortage in Canada. Lacroix, Julie D.; Mahoney, John E.; Knoll, Greg A. // Canadian Journal of Surgery;Feb2004, Vol. 47 Issue 1, p10 

    Introduction: There is a chronic shortage of cadaveric organ donors for renal transplantation, which might be solved by the use of non-heart-beating donors (patients who suffer cardiac arrest and whose kidneys are harvested subsequently when irreversible heart and respiratory function occur)....

  • Determining the Acceptance of Cadaveric Livers Using an Implicit Model of the Waiting List. Alagoz, Oguzhan; Maillart, Lisa M.; Schaefer, Andrew J.; Roberts, Mark S. // Operations Research;Jan/Feb2007, Vol. 55 Issue 1, p24 

    The only available therapy for patients with end-stage liver disease is organ transplantation. In the United States, patients with end-stage liver disease are placed on a waiting list and offered livers based on location and waiting time, as well as current and past health. Although there is a...

  • Early results of a controlled non-heart-beating kidney donor programme. Akoh, Jacob A.; Denton, Mark D.; Bradshaw, Sharon B.; Rana, Tahawar A.; Walker, Martin B. // Nephrology Dialysis Transplantation;Jun2009, Vol. 24 Issue 6, p1992 

    Background. We present our experience of a controlled non-heart beating donation (CNHBD) programme in a University Hospital. Methods. Data from all referrals for CNHBD between January 2005 and January 2008 were collected prospectively. Donor and recipient data were analysed and compared to other...

  • Kidney grafts from brain dead donors: Inferior quality or opportunity for improvement? Bos, E. M.; Leuvenink, H. G. D.; van Goor, H.; Ploeg, R. J. // Kidney International;Oct2007, Vol. 72 Issue 7, p797 

    Major improvements in immunosuppressive treatment, surgical techniques, and treatment of post-transplant complications have contributed considerably to improved outcome in renal transplantation over the past decades. Yet, these accomplishments have not led to similar improvements in transplant...

  • Maimonides's cooling period and organ retrieval. McAlister, Vivian // Canadian Journal of Surgery;Feb2004, Vol. 47 Issue 1, p8 

    Comments on the use of non-heart-beating donors in organ transplantation. Diagnosis of death codified by Maimonides; Statistics on cadaveric organ donation; Ethical aspects of non-heart-beating organ donation.

  • Non-heart-beating organ donation in Canada: Time to proceed? Knoll, Greg A.; Mahoney, John E. // CMAJ: Canadian Medical Association Journal;8/19/2003, Vol. 169 Issue 4, p302 

    Assesses the factors that call for the initiation of non-heart-beating organ donation (NHBD) practice in Canada as of 2003. Reason behind the refusal of Canadian physicians to adopt NHBD; Background on the concept of NHBD; Groups that endorsed the use of NHBD in the country.

  • Response to organ shortage: kidney retrieval programme using non-heart beating donors. Varty, K.; Veitch, P.S.; Morgan, J.D.T.; Kehinde, E.O.; Donnelly, P.K.; Bell, P.R.F. // BMJ: British Medical Journal (International Edition);2/26/94, Vol. 308 Issue 6928, p575 

    Focuses on the kidney retrieval program using non-heart beating donors as a response to organ shortage. Concerns on the dwindling number of organ donors; Retrieval of kidneys from asystolic donors using in situ renal perfusion; Selection of donors for kidney transplantation.

  • Acute Rejection: The Only Significant Risk Factor in NHBD Kidney Transplants.  // Kidney;Jul/Aug99, Vol. 8 Issue 4, p165 

    Examines long-term renal function in non-heart-beating donor kidney transplantation. Identification of risk factors for graft failure; Incidence of delayed graft function.

  • Noteworthy Results Attained with Use of Non-Heart-Beating Kidneys. Ota, K.; Takahashi, K.; Uchida, K. // Kidney;Nov/Dec2000, Vol. 9 Issue 6, p264 

    Focuses on a study which reported the outcome of a large number of transplant recipients of non-heart beating cadaver donor and living donor kidneys who were treated with cyclosporine. Methodology; Results; Conclusion.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics