TITLE

Adrenocortical Carcinoma With Concomitant Myelolipoma in a Patient With Hyperaldosteronism

AUTHOR(S)
Sun, Xichun; Ayala, Alberto; Castro, Claudia Y.
PUB. DATE
June 2005
SOURCE
Archives of Pathology & Laboratory Medicine;Jun2005, Vol. 129 Issue 6, pe144
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We present a case of aldosterone-secreting adrenocortical carcinoma with concomitant myelolipoma. To the best of our knowledge, this is the first such reported case. The patient was a 43-year-old man with severe hypertension. Clinical workup revealed an increased serum aldosterone level, hypokalemia, and metabolic alkalosis, and a left ad- renal mass was found on computed tomography. The patient underwent a unilateral adrenalectomy, which led to improvement in blood pressure, the serum potassium level, and aldosterone concentration. The tumor weighed 70 g and measured 5.0 cm. On microscopic examination, we found necrosis, focal cytologic atypia, diffuse eosinophilic cells comprising more than 75% of the tumor, 5 to 7 mitotic figures per 50 high-power fields, rare atypical mitosis, and venous invasion. At the periphery of the tumor but within the capsule, microscopic areas of myelolipoma were seen. Ki-67 staining was positive in 20% of the tumor cells. Although rare, aldosterone-secreting carcinoma associated with myelolipoma should be included in the differential diagnosis of adrenal gland masses.
ACCESSION #
17199572

 

Related Articles

  • Aldosterone and in vivo mineralocorticoid activity in normotensive and hypertensive man. Skrabal, Falko // Journal of the Royal Society of Medicine;Apr1979, Vol. 72 Issue 4, p252 

    The article presents further analysis of the data already published about aldosterone and in vivo mineralocorticoid activity in normotensive and hypertensive man. It includes additional studies in 81 patients with essential hypertension, in 20 patients with primary or secondary...

  • A Rare Combination Consisting of Primary Hyperaldosteronism and Glucagonoma. Abe, Hideki; Kubota, Keiichi; Noie, Tamaki; Kimura, Wataru; Makuuchi, Masatoshi // American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1397 

    A 59-yr-old man with multiple pancreatic tumors is presented. Previously, he had undergone left adrenalectomy for primary hyperaldosteronism and left nephrectomy for renal cell carcinoma at the ages of 39 and 55 yr. respectively. This time, 3 yr after removal of renal cancer, two solid lesions...

  • An Adrenal Mass in a 54-Year-Old Man. Stephany, Joshua D.; Pearl, Gary S. // Archives of Pathology & Laboratory Medicine;Jul2003, Vol. 127 Issue 7, p883 

    Presents a case study of a 54-year-old black man with an adrenal mass who was diagnosed with adrenocortical adenoma with spironolactone bodies. Medical history of the patient; Cause of primary hyperaldosteronism; Information on spironolactone.

  • A patient with concurrent primary aldosteronism and Page kidney. Chin-Chi Kuo; Huan-Lun Hsu; Chao-Yuan Huang; Kao-Lang Liu; Vin-Cent Wu; Ching-Wei Tsai; Wei-Jie Wang // Endocrine (1355008X);Aug2010, Vol. 38 Issue 1, p6 

    The ratio of aldosterone-to-renin activity is currently recommended as a screening test for primary aldosteronism (PA). There are many factors interfering the interpretation of aldosterone-renin ratio (ARR) and could hamper in-time diagnosis of PA. Here, we first report a patient with underlying...

  • Long-Term Results of Adrenalectomy in Patients with Aldosterone-Producing Adenomas: Multivariate Analysis of Factors Affecting Unresolved Hypertension and Review of the Literature. Lumachi, Franco; Ermani, Mario; Basso, Stefano M. M.; Armanini, Decio; Iacobone, Maurizio; Favia, Gennaro // American Surgeon;Oct2005, Vol. 71 Issue 10, p864 

    The long-term surgical cure rate of patients with primary aldosteronism varies widely, and causes of persistent hypertension are not completely established. We reviewed retrospectively charts from 98 patients (range, 19-70 years old) with aldosterone-producing adenomas who underwent unilateral...

  • Conn's syndrome due to a renin-responsive adrenal adenoma. Miles, S.M.; Moult, P.J.A.; Hoffbrand, B.I. // Journal of the Royal Society of Medicine;May1993, Vol. 86 Issue 5, p294 

    Primary aldosteronism was first described in 1955 by Conn and is characterized by the findings of hypertension, hypokalaemia, suppressed plasma renin activity and increased aldosterone production. The incidence is estimated at between 0.05% to 2% of all cases of hypertension. There are four main...

  • Ethinylestradiol/drospirenone.  // Reactions Weekly;7/19/2008, Issue 1211, p16 

    The article describes the case of a 34-year-old woman who was given a false-positive diagnosis of primary aldosteronism. The patient was given the said diagnosis when she was taking ethinylestradiol/drospirenone. Her aldosterone-to-renin ratio (ARR) was taken at different times during her...

  • A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male. Wanta, Stephen M.; Basina, Marina; Chang, Steven D.; Chang, Daniel T.; Ford, James M.; Greco, Ralph; Kingham, Kerry; Merritt, Robert E.; Kunz, Pamela L. // Rare Tumors;2011, Vol. 3 Issue 4, p141 

    We report a rare synchronous presentation of adrenocortical carcinoma (ACC) and papillary thyroid carcinoma (PTC). A 31-year-old male first presented with a large left adrenal mass that was identified during the workup for refractory hypertension due to hyperaldosteronism. The mass was removed...

  • Primary aldosteronism: from bench to bedside. Sukor, Norlela // Endocrine (1355008X);Feb2012, Vol. 41 Issue 1, p31 

    Primary aldosteronism is now thought to be the commonest potentially curable and specifically treatable form of hypertension. The detection of primary aldosteronism is of utmost importance not only because it provides an opportunity for a targeted treatment, but also because it has been...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics