TITLE

CLINICAL RELEVANCE OF PROTEINASE ACTIVATED RECEPTORS (PARS) IN THE GUT

AUTHOR(S)
Vergnolle, N.
PUB. DATE
June 2005
SOURCE
Gut;Jun2005, Vol. 54 Issue 6, p867
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents information on proteinase. Of all the body systems, the gastrointestinal tract is the most exposed to proteinases. Under physiological conditions, digestive proteinases such as trypsin are released in pancreatic ducts and then into the upper gastrointestinal tract, during and alter meals. The forms of proteinases released in the pancreatic duct and intestinal lumen are inactive and need to be cleaved to be activated. This cleavage occurs in the gut lumen where a constant balance between proteolytic activity and the presence of proteinase inhibitors persists in order to fulfill the digestive functions of the gastrointestinal tract, but also at the same time to protect mucosal surfaces from exposure to proteolytic enzymes.
ACCESSION #
17176790

 

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