Depression: more than just serotonin

Secko, David
June 2005
CMAJ: Canadian Medical Association Journal;6/7/2005, Vol. 172 Issue 12, p1551
Academic Journal
Discusses research being done on depression, dopamine and serotonin. Reference to a study by F. M. Zhou, Y. Liang et al, published in the 2005 issue of "Neuron"; Mechanism of action of serotonin transporters; Role of serotonin in the pathophysiology of depression.


Related Articles

  • Antidepressants Alter Mesostriatal Dopamine Interactions with Serotonin Signaling. Zhou, Fu-Ming; Dani, John A. // Current Psychiatry Reviews;2006, Vol. 2 Issue 4, p453 

    The striatum and its dense dopaminergic innervation originating in the substantia nigra pars compacta and the ventral tegmental area compose the mesostriatal dopamine system. The nigrostriatal system is particularly involved in habit learning and in motor coordination; the dopaminergic...

  • Abnormal temporal difference reward-learning signals in major depression. P. Kumar; G. Waiter; T. Ahearn; M. Milders; I. Reid; J. D. Steele // Brain: A Journal of Neurology;Aug2008, Vol. 131 Issue 8, p2084 

    Anhedonia is a core symptom of major depressive disorder (MDD), long thought to be associated with reduced dopaminergic function. However, most antidepressants do not act directly on the dopamine system and all antidepressants have a delayed full therapeutic effect. Recently, it has been...

  • Inflamed brains can trigger the blues, studies suggest. Sinha, Gunjan // Nature Medicine;Oct2004, Vol. 10 Issue 10, p1007 

    Proposes that inflammation may be linked to depression. Alteration of the levels of neurotransmitters such as dopamine and serotonin in the brain by signaling molecules or cytokines; Involvement of several separate brain systems in the complex disorder of depression.

  • Association of a Critical CSF Tryptophan Threshold Level with Depressive Relapse. Salomon, Ronald M.; Kennedy, John S.; Johnson, Benjamin W.; Schmidt, Dennis E.; Kwentus, Joseph; Gwirtsman, Harry E.; Ebert, Michael H. // Neuropsychopharmacology;May2003, Vol. 28 Issue 5, p956 

    This work studies association between relapse during acute tryptophan depletion (ATD) and CSF level of tryptophan (TRP) in remitted depressives treated with sertraline or bupropion. Eight medication-responding depressives ingested an ATD amino acid mixture during 48-h continuous CSF sampling...

  • The Antidepressant Myth. HELLER, DANIEL // Naturopathic Doctor News & Review;Mar2014, Vol. 10 Issue 3, p1 

    The article discusses the myth on antidepressants, presenting arguments against the claim of experts that brain chemical imbalances such as diseases of disordered neurotransmitters, particularly monoamines serotonin, norepinephrine and dopamine, result in mental illness and depression. The...

  • A 40-basepair VNTR polymorphism in the dopamine transporter (DAT1) gene and the rapid response to antidepressant treatment. Kirchheiner, J.; Nickchen, K.; Sasse, J.; Bauer, M.; Roots, I.; Brockmöller, J. // Pharmacogenomics Journal;2007, Vol. 7 Issue 1, p48 

    Finding predictors of the response to antidepressant therapy is a major goal of molecular psychiatry. The genes encoding the serotonin (SERT) and dopamine (DAT1) transporters are among the possible candidate genes modulating an individual's antidepressant response. In a naturalistic prospective...

  • Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms. Gannon, Robert L.; Millan, Mark J.; Gannon, R. L. // Psychopharmacology;Dec2007, Vol. 195 Issue 3, p325 

    Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for the treatment of anxiodepressive states that are often associated with perturbed circadian rhythms including, in certain patients, phase advances. Surprisingly, the influence of SSRIs upon circadian activity rhythms has...

  • Plasma Levels of Monoamines and Behavioral Stress: Animal Model of Depression. Mondal, Amal Chandra // Al Ameen Journal of Medical Sciences;2011, Vol. 4 Issue 4, p370 

    Background: The functions of the monoamine neurotransmitters dopamine (DA) and serotonin (5-HT) in the etiology and treatment of depressive disorders are currently an area of intense research. Much of this research has focused on a relevant animal model of depression as a means of understanding...

  • UNDERSTANDING THE RELATIONSHIP BETWEEN PAIN AND DEPRESSION. ANDREI, Ioana Anca; FRUNZA, Alina Alexandra; PUIU, Maria Gabriela; MIHAILESCU, Ilinca; PATRICHI, Bogdan Eduard; MANEA, Mirela // Romanian Journal of Child & Adolescent Psychiatry;Jan-Jun2015, Vol. 3 Issue 1, p15 

    Depression and physical pain are considered to be linked together in a partially understood, complex relationship. The pain intensity present in major depressive disorder is a predictor for the remission time, degree of impairment, clinical resolution and health care costs. Among the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics